Registration Dossier
Registration Dossier
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EC number: 202-855-7 | CAS number: 100-47-0
Specific investigations: other studies
Administrative data
- Endpoint:
- hepatotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Analysis of plasma bilirubin concentration, glutamic pyruvic transaminase (GPT) activity, and hepatioc triglyceride concentration 24 h after i.p. injection of test material. Blood was collected by aortic puncture in heparin-treated syringes.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Benzonitrile
- EC Number:
- 202-855-7
- EC Name:
- Benzonitrile
- Cas Number:
- 100-47-0
- Molecular formula:
- C7H5N
- IUPAC Name:
- benzonitrile
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
- Reference substance name:
- Terephthalonitrile
- EC Number:
- 210-783-2
- EC Name:
- Terephthalonitrile
- Cas Number:
- 623-26-7
- Molecular formula:
- C8H4N2
- IUPAC Name:
- terephthalonitrile
- Reference substance name:
- Benzene-1,3-dicarbonitrile
- EC Number:
- 210-933-7
- EC Name:
- Benzene-1,3-dicarbonitrile
- Cas Number:
- 626-17-5
- Molecular formula:
- C8H4N2
- IUPAC Name:
- isophthalonitrile
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- single injection
- Post exposure period:
- 24h
Doses / concentrations
- Dose / conc.:
- 150 mg/kg bw/day (nominal)
- Remarks:
- 1.5 mmol/kg were reproted
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
- Details on results:
- Benzonitrile is not hepatotoxic to rats under conditions of this study at doses of 1.5 mmol/kg.
Applicant's summary and conclusion
- Conclusions:
- Benzonitrile is not hepatotoxic to rats under conditions of this study at doses of 1.5 mmol/kg.
- Executive summary:
Benzonitrile is not hepatotoxic to rats under conditions of this study at doses of 1.5 mmol/kg.
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