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EC number: 209-810-0 | CAS number: 593-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31. May 1967 - 05. Jun 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions (1, 5, 15 min and 20 h exposure duration, no 72 h reading, 7-d observation period, 60% aqueous solution of test substance).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (limited documentation, 1, 5, 15 min and 20 h exposure duration, no 72 h-reading, observation period 7 d, 2 animals, 60% aqueous solution of test substance)
- GLP compliance:
- no
Test material
- Reference substance name:
- Trimethylammonium chloride
- EC Number:
- 209-810-0
- EC Name:
- Trimethylammonium chloride
- Cas Number:
- 593-81-7
- Molecular formula:
- C3H9N.ClH
- IUPAC Name:
- N,N-dimethylmethanaminium chloride
- Details on test material:
- - Name of test substance (as cited in study report): Trimethylaminhydrochlorid
- Analytical purity: approx. 60 - 65% aqueous solution
- Impurities: 0.2 - 1% Trimethylamin
- Physical state: liquid
- Subtance number: XVII/118
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3.56 and 3.58 kg
no additional information given
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other: untreated site served as control
- Amount / concentration applied:
- test substance (approx. 60% aqueous solution; 0.2 – 1% Trimethylamin)
- Duration of treatment / exposure:
- 1, 5, 15 min and 20 h
- Observation period:
- 7 d (readings after treatement: 24 h, 48 h, 5 d and 7 d)
- Number of animals:
- 2 (females)
- Details on study design:
- TEST SITE
- Area of exposure: no data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin was washed with Lutrol (conc.) and 50% in water.
- Time after start of exposure: 1, 5, 15 min or 20 h.
SCORING SYSTEM: evaluation was performed according to the Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- (20 h exposure)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Remarks on result:
- other: slight, line-like necrosis at day 5, scaling at day 7
- Remarks:
- This value was derived for the following time points: mean over 24 and 48 h. 72 hours were not evaluated.
- Irritation parameter:
- erythema score
- Remarks:
- (20 h exposure)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Remarks on result:
- other: see 'Remarks'
- Remarks:
- This value was derived for the following time points: mean over 24 and 48 h. 72 hours were not evaluated.
- Irritation parameter:
- edema score
- Remarks:
- (20 h exposure)
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 5 days
- Remarks on result:
- other: slight, line-like necrosis at day 5, scaling at day 7
- Remarks:
- This value was derived for the following time points: mean over 24 and 48 h. 72 hours were not evaluated.
- Irritation parameter:
- edema score
- Remarks:
- (20 h exposure)
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: see 'Remarks'
- Remarks:
- This value was derived for the following time points: mean over 24 and 48 h. 72 hours were not evaluated.
- Other effects:
- Body weights (day 0 - day 7):
animal#1: 3.58 kg - 3.36 kg
animal#2: 3.56 kg - 3.34 kg
Any other information on results incl. tables
Table 1: Details on results: Skin irritation
Exposure |
Reading |
Animal#1 |
Animal#2 |
||||
Erythema |
Edema |
Remarks |
Erythema |
Edema |
Remarks |
||
1 min |
All timepoints |
0 |
0 |
- |
0 |
0 |
- |
5 min |
All timepoints |
0 |
0 |
- |
0 |
0 |
- |
15 min |
All timepoints |
0 |
0 |
- |
0 |
0 |
- |
20 h |
24 h |
3 |
2 |
- |
1 |
0 |
- |
48 h |
3 |
2 |
- |
0 |
0 |
- |
|
5 d |
0 |
0 |
Line-like necrosis |
0 |
0 |
- |
|
7 d |
0 |
0 |
Scaling |
0 |
0 |
- |
|
Mean (24, 48 h) |
3.0 |
2.0 |
- |
0.5 |
0.0 |
- |
Because of the strong differences between the 2 animals after test substance application, the assessment is based on the reaction of animal#1 in a worst case scenario.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The test substance is considered as skin-irritant. Despite of restrictions regarding the actual guideline, the study is considered suitable for assessment
- Executive summary:
In a primary dermal irritation study performed according to a protocol similar to the OECD test guideline 404, the test substance (approx. 60% aqueous solution; 0.2 – 1% Trimethylamin) was applied to the intact skin of 2 rabbits (Vienna White) under occlusive conditions for 1, 5, 15 min and 20 h. Erythema (mean scores (24 – 48 h): 3.00 and 0.50) was observed, but was fully reversible within 5 d and 48 h, respectively. Edema (scores: 2.00 and 0.00) was reversible within 5 d. The scores of one animal are above the threshold of classification, thus in a worst case scenario with regard to this animal, the test substance is considered irritant. The conditions were very harsh compared to the conditions requested by the guideline (20 h instead of 4 h treatment, occlusive instead of semiocclusive treatment) and no 72 h scoring was performed. But as the test substance concentration was only 60% and a strong reaction was observed in 1 of 2 animals, an irritant potential of the test substance is assumed. Besides the observed erythema, line-like necrosis was described on day 5. As on day 7 only scaling is reported, it is not considered to be of relevance for classification.
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