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Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
412-440-4
EC Name:
-
Cas Number:
2725-22-6
Molecular formula:
C33-H39-N3-O2
IUPAC Name:
2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-(octyloxy)phenol

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5 rats/each sex
5 Females
5 male
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Mortality:
Male: 5000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 5000 mg/kg bw; Number of animals: 5; Number of deaths:0
Clinical signs:
other: Signs of toxicity ralated to does levels: No significant clinical signs were produced at any time
Gross pathology:
Effects on organs:
No gross lesions or abnormalities were noted during necropsy

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
Acute oral toxicity study was performed according to OECD Guideline 401 (Acute Oral Toxicity) to determine the toxic nature of test chemical on rats. An LD50 of >5000 mg/kg bw was determined indicating that the test chemical is not toxic in nature and falls under category ‘Not classified’.
Executive summary:

Acute oral toxicity study was performed according to OECD Guideline 401 (Acute Oral Toxicity) to determine the toxic nature of test chemical on rats. 5 male and 5 female Sprague-Dawley rats were administered test chemical at a dose range of 5000 mg/kg bw via oral gavage route. Vehicle used was corn oil. No mortality was observed after the test, no significant clinical signs were produced at any time and no gross lesions or abnormalities were noted during necropsy. An LD50 of >5000 mg/kg bw was determined indicating that the test chemical is not toxic in nature and falls under category ‘Not classified’.