Registration Dossier
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EC number: 200-273-8 | CAS number: 56-41-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effect at a concentration of 1000 mg/L test item.
Key value for chemical safety assessment
Additional information
The performed GLP main experiment did not produce suitable results. In the only treatment group of nominal 500 mg test item/L, a high turbidity occurred in the replicates containing algae. This turbidity was caused by a contamination with microorganisms which could not be inhibited performing the test under sterile conditions. Due to the turbidity and/or interfering effects with the contamination the algae growth in the only treatment group was reduced and the low inhibitions allowed in a limit test were exceeded.
In accordance with Annex XI No. 1.2 there is sufficient weight of evidence from several independent sources of information leading to the assumption/conclusion that the substance does not cause aquatic toxicity to algae. Despite of that the described limit test was performed.
Although the main part of the above mentioned limit test did not produce reliable results the non-GLP pre-experiment indicated that no effect was caused by the test item itself up to 1000 mg test item/L. A cell count of the cell density at this concentration showed no inhibition in the cell number in comparison to the control cell density. Therefore the completed part of the study confirmed the assumption that L-alanine does not cause toxicity to aquatic algae and cyanobacteria.
This is not surprising. L-alanine is a naturally occurring essential amino acid which is omnipresent in nature. It is a basic metabolit and building block of all living organisms and cells and is also a nutrient for algae. Thus significant toxicity to algae can be excluded.
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