Registration Dossier
Registration Dossier
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EC number: 206-761-7 | CAS number: 373-02-4
Endpoint summary
Administrative data
Description of key information
Value used for CSA: not irritating (skin and eye)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A recent study demonstrated that nickel acetate does not cause skin irritation or corrosion. The skin irritation study was conducted in rabbits according to OECD Test #404 - Acute Dermal Irritation/Corrosion guidelines (Product Safety Labs, 2013). Three healthy female rabbits were exposed via the skin to Ni acetate to determine if the test substance had the potential to produce irritation. No reactions were observed in any of the animals.
Data regarding eye irritation caused by Ni acetate are read-across from Ni sulphate because nickel acetate has similar water solubility to nickel sulphate. See read-across. Ni sulphate has been demonstrated not to be an eye irritant in experimental animals (SLI, 1999).
The following information is taken into account for any hazard / risk assessment:
Data regarding skin irritation of Ni acetate were negative in animals for skin irritation. Data regarding eye irritation of Ni acetate are read-across from Ni sulphate. Ni sulphate has been demonstrated not to be an eye irritant in experimental animals. The available data do not allow any conclusion on respiratory irritation.
Justification for classification or non-classification
Ni acetate is not classified for skin or eye irritation according to the 1st ATP to the CLP Regulation. Background information regarding available data for this endpoint has been provided in the discussion section above.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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