Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-269-7 | CAS number: 118-69-4
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,6-dichlorotoluene
- EC Number:
- 204-269-7
- EC Name:
- 2,6-dichlorotoluene
- Cas Number:
- 118-69-4
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- 1,3-dichloro-2-methylbenzene
- Details on test material:
- - Analytical purity: 99.2%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- Male: For 2 weeks prior to mating, 2 weeks of mating and 2 weeks after mating.
Female: For 2 weeks prior to mating, 2 weeks of mating and throughout pregnancy up till day 3 postarm. - Frequency of treatment:
- Daily
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
30mg/kg/day
Basis:
other: in corn oil
- Remarks:
- Doses / Concentrations:
100mg/kg/day
Basis:
other: in corn oil
- Remarks:
- Doses / Concentrations:
300mg/kg/day
Basis:
other: in corn oil
- Remarks:
- Doses / Concentrations:
1000mg/kg/day
Basis:
other: in corn oil
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 1 000 mg/kg bw/day
- Sex:
- male
- Dose descriptor:
- NOEL
- Effect level:
- 100 mg/kg bw/day
- Sex:
- female
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOEL
- Generation:
- F1
- Effect level:
- 300 mg/kg bw/day
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
No adverse effects of 2,6-dichlorotoluene at any dose level were noted for copulation, fertility or delivery. Numbers of dead pups were increased and viability on postnatal day 4 was decreased in the 300 and 1000 mg/kg groups. Pup weights on postnatal day 4 tended to be decreased in the 1000 mg/kg group. No morphological abnormalities were found in pups of any 2,6-dichlorotoluene -treated group.
Applicant's summary and conclusion
- Conclusions:
- NOELs for reproductive and developmental toxicity of 2,6-dichlorotoluene are considered to be 1000 mg/kg/day in males, 100 mg/kg/day in females and 300 mg/kg/day in offspring.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
