Registration Dossier
Registration Dossier
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EC number: 202-625-6 | CAS number: 97-99-4
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- the study does not need to be conducted because the substance has no ionic structure
Reference
Description of key information
Dissociation constant [tetrahydrofurfuryl alcohol]: not relevant
Key value for chemical safety assessment
Additional information
In accordance with section 1 of REACH Annex XI, the study does not need to be conducted for the substance because there are no groups present in the molecule that are expected to ionize within an environmentally relevant pH range. However, the dissociation constant of the hydroxyl group has been predicted using SPARC (pKa = 15).
While the hydroxyl group is ionisable, tetrahydrofurfuryl alcohol is an extremely weak acid and will only dissociate under strongly basic conditions. In the range of pH usually considered relevant to the human body and environment, i.e. pH 2-9, the substance will be non-ionised. Therefore, there is no need to conduct further testing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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