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Diss Factsheets
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EC number: 202-879-8 | CAS number: 100-69-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was undertaken in a corporate laboratory according to a standardized protocol, at a time when reporting of minimal data was routine. Only basic data is provided in this report.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test material was instilled into the eyes of rabbits , and observations made on the effect on the eye. Fluorescein stain was applied to the eye to detect corneal damage.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-vinylpyridine
- EC Number:
- 202-879-8
- EC Name:
- 2-vinylpyridine
- Cas Number:
- 100-69-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 2-ethenylpyridine
- Details on test material:
- test material = 98.95% pure
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- 3 animals per test/ sex not indicated
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- no information
- Observation period (in vivo):
- no information
- Number of animals or in vitro replicates:
- 3 animals per test (washed and unwashed eyes)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 3
- Reversibility:
- not fully reversible within:
- Irritant / corrosive response data:
- Strong eye irritant in unwashed eyes; moderate eye irritant in washed eyes.
Any other information on results incl. tables
unwashed eyes: 3/3 showed strong irritation
washed eyes: 3/3 showed moderate irritation
Corneal and adnexal staining of fluorescein in all washed and unwashed eyes. Prompt irrigation with distilled water was pallative.
Applicant's summary and conclusion
- Interpretation of results:
- Category I
- Remarks:
- Migrated information Corneal opacity but there is no qualitative score Criteria used for interpretation of results: EU
- Conclusions:
- Rabbit eye irritation was strong in unwashed (3/3) and moderate (3/3) in washed eyes; there was corneal and adnexal staining of fluorescein in all washed and unwashed eyes. Prompt irrigation with distilled water was palliative. 2VP is considered a severe eye irritant. While only minimal data is reported, consideration of repeating this study is inappropriate, due to the corrosive nature of the substance, and acceptance of a Category 1 classification.
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