Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

Inhalation:
Remove to fresh air - Call a physician or Poison Control Centre immediately - If breathing is irregular or stopped, administer artificial respiration - In case of lung irritation, first treatment with dexametason aerosol )spray) - Give oxygen

Skin contact:
Wipe skin with absorbent paper - Wash off immediately with soap and plenty of water - Rinse with very diluted acid - Obtain medical attention.

Eye contact:
In case of eye contact, remove contact lens and rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes - Protect
unharmed eye - Ophthalmic treatment necessary.

Ingestion:
Prevent vomiting if possible - Do not induce vomiting - Clean mouth with water and drink afterwards plenty of water - If accidentally swallowed
obtain immediate medical attention - Never give anything by mouth to an unconscious person.

Notes to physician:

Risks:
Risk of pneumonia - Risk of spasmogenic effect - Health injuries may be delayed - Later control for pneumonia and lung oedema.

Treatment:
Exposure quickly causes a strong corrosive action upon all body tissue - Aspiration may cause pulmonary oedema and pneumonitis - Prompt
administration of corticosteroid spray - Calcium gluconate solution - Call a physician or Poison Control Centre immediately - First aid,
decontamination, symptomatic treatment - Symptoms of poisoning may not appear for several hours - Keep under medical supervision for at least
48 hours

Fire-fighting measures

Suitable extinguishing media: water spray, alcohol-resistant foam.

Extinguishing media which must not be used for safety reasons: carbon dioxide (CO2), dry powder

Special hazards during fire fighting:
In case of fire or heat toxic/harmful gases, vapours and pyrolysis products may be formed of the substance, e.g. Carbon monoxide (CO), Nitrogen
oxides (NOx), Ammonia (NH3) - In case of area fire pressure increase and danger of.

Specific hazards during fire fighting:
Exposure to decomposition products may be a hazard to health - May form explosive mixtures with air - Flash back possible over considerable
distance - Vapours are heavier than air combustible material.

Fire fighting / advice:
Collect contaminated fire extinguishing water seperately. This must not be discharged into drains - Fire residues and contaminated fire
extinguishing water must be disposed of in accordance with local regulations - Cool containers / tanks with water spray.

Special protective equipment for fire-fighters:
In the event of fire, wear self-contained breathing apparatus and full protection clothing - Do not inhale explosion and combustion gases.

Accidental release measures

Personal precautions:
Ensure adequate ventilation - Keep unauthorized persons away - Keep away from ignition sources - Wear respiratory protection - Immediately
evacuate danger zone and seek safe cover - Wear self-contained breathing apparatus and protective suit.

Environmental precautions: Do not allow to reach into waters, drains or the ground.

Methods for cleaning up:
Pick up mechanical after absorption - Fill in labelled, resealable container - Clean contaminated surface thoroughly with: ammonium thiosulphate,
5% aqueous solution - Do not allow to reach into waters, drains or the ground - Ensure sufficient ventilation - Flush with water - Soak up with inert
absorbent material and dispose of as hazardous waste.

Suitable binder or medium for neutralisation: Chemical binders containing acids - Solid ammonium thiosulphate.

Additional advice in case of release: Odour fighting with: ammonium thiosulphate, 5% aqueous solution.

Handling and storage

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 18(4). Site documentation to support
safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with
risk-based management systems is available at each Manufacturing site. Written confirmation of application of Strictly Controlled Conditions has
been received from every affected Distributor and Downstream Manufacturer/User of the Registrant’s intermediate.

Handling

Protection measure : Vapours are heavier than air and may spread along floors - Provide exhaust ventilation near floor ground.

Advice on safe handling :
Use the required personal safety equipment for all types of work (see exposure controls/personal protection) - Containers only open under
extraction system - Refill and handle product only in closed system - Ensure sufficient ventilation - Avoid contact with the skin and the eyes - Do
not inhale vapours/dusts/aerosols - Keep away from open flames, hot surfaces and sources of ignition - Avoid moisture - Avoid spilling and
spraying within closed rooms - Container hazardous when empty - Explosive on ignition.

Appliance requirements :
Solvent-resistant - Do not use spark-producing tools - Earthing required - Unsuitable material: rubber, metal, heavy metal.

Advice on protection against fire and explosion:
No smoking - Keep away from open flames, hot surfaces and sources of ignition - Vapours can form explosive mixtures with air - Take measures
to avoid electrostatic charges - In case of fire cool endangered containers with water combustible material - Vapours can cross over large
distances to ignition sources.

Storage

Requirements for storage areas and containers: Keep locked up - Prevent unauthorized access.

Storage container : No glass, unbreakable containers

German storage class : 3A

Advice on common storage : Do not store with: Fire-promoting substances, oxidizing solid, acids.

Storage temperature : <= 35 °C

Transport information

Land transport (ADR/RID)

UN number:
UN 1921
Proper shipping name and description:
PROPYLENEIMINE, STABILIZED
Chemical name:
2-methylaziridine
Language:
English
Class:
3 (6.1)
Packaging group:
I
Labels:
EC Label
Restricted to professional users.
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
UN 1921
Proper shipping name and description:
PROPYLENEIMINE, STABILIZED
Chemical name:
2-methylaziridine
Language:
English
Class:
3 (6.1)
Packaging group:
I
Labels:
EC Label
Restricted to professional users.
Remarksopen allclose all

Marine transport (IMDG)

UN number:
UN 1921
Proper shipping name and description:
PROPYLENEIMINE, STABILIZED
Chemical name:
2-methylaziridine
Class:
3 (6.1)
Packaging group:
I
Labels:
EC Label
Restricted to professional users.
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
UN 1921
Proper shipping name and description:
PROPYLENEIMINE, STABILIZED
Chemical name:
2-methylaziridine
Class:
3 (6.1)
Packaging group:
I
Labels:
EC Label
Restricted to professional users.
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 18(4). Site documentation to support
safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with
risk-based management systems is available at each Manufacturing site. Written confirmation of application of Strictly Controlled Conditions has
been received from every affected Distributor and Downstream Manufacturer/User of the Registrant’s intermediate.

CMR-classification : Legal regulation: Carcinogenic Category 2

Limit value for occupational safety
Remarks : Technical rules hazardous components (TRGS 900-Germany) - Technical rules hazardous components (TRGS 901-Germany)

Country : The Netherlands
Threshold limit value foroccupational exposure: 0,00061 mg/m3
Remarks : Limit value - Eight hours (8-hr TWA)

Country : France
Threshold limit value for occupational exposure: 50 mg/m3, 20 ppm
Remarks : Limit value - Eight hours (8-hr TWA)

Country : Spain
Threshold limit value for occupational exposure: 4,7 mg/m3, 2 ppm
Remarks : Limit value - Eight hours (8-hr TWA)

Country : United States of America
Threshold limit value for occupational exposure: 5 mg/m3, 2 ppm
Remarks : OSHA PEL

Country : United States of America
Threshold limit value for occupational exposure: 5 mg/m3, 2 ppm
Remarks : NIOSH (National Institute for Occupational Safety and Health)

Personal protective equipment

Respiratory protection : Self-contained protective breathing apparatus

Hand protection :
Advice(s): Check for imperviousness/impermeability prior to use - Note breakthrough times and swelling properties of the material - Change
contaminated gloves - Remark: The data are based on literature, data of manufacturers of gloves or analogies of similar substances. The duration of wearing may vary depending on e.g. temperature or other factors - Wear suitable gloves. Suitable materials: In case of full contact: Material:
butyl-rubber, Minimal degradation time: 120 min.

Eye protection : Face protection umbrella, Basket goggles, tight

Skin and body protection :
To protect against direct skin contact personal protective equipment (in addition to normal working clothes) is required - Chemical protection
clothing - Antistatic protective suit - antistatic boots.

Hygiene measures :
When using do not eat, drink or smoke - Keep away from food, drink and animal feedingstuffs - Change contaminated/soaked clothing - Bath or
shower at end of work - Daily change of work clothing required - Prophylactic skin protection is necessary - In the immediate vicinity of the
working area: Eye douches must be provided and their location must be marked conspicuously - Emergency showers must be installed - Do not inhale gases/vapours/aerosols - Avoid contact with the skin and the eyes - Avoid spillage and leakage - Do not wear contact lenses.

Stability and reactivity

Conditions to avoid : Warming, Contact with the substances named below
Materials to avoid : acids, Atmospheric moisture., carbon dioxide (CO2), Non-ferrous heavy metal, powdered metal salts, heavy metal salts, heavy
metals.

Hazardous reactions :
Violent polymerization may be caused by: acids - Possibly forms explosive metal compounds with heavy metals - Polymerization can occur -
Vapours are heavier than air - Production of explosive vapour-air-mixtures - Reaction with: strong oxidizing agents

Hazardous decomposition products:
Carbon oxides, Nitrogen oxides (NOx), (in case of fire or warming/heating) - Production of toxic/hazardous to health or corrosive/irritant
products.

Risk classification according to VbF: B: Flash point < 21°C, at 15°C soluble in water.

Disposal considerations

Disposal regulatory information :
Method of disposal: Dispose of in accordance with local authorities - Dispose of in accordance with local authorities regulations - Can be disposed of in a suitable incinerator

Information to disposal and packing:
Information for packing: Uncleaned empty containers are to be handled as the substance contained itself.