Registration Dossier
Registration Dossier
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EC number: 202-980-7 | CAS number: 101-83-7
Endpoint summary
Administrative data
Description of key information
Repeated oral dose toxicity was assessed by a subacute toxicity study (28 days, Japanese Guideline) and in an OECD TG 421 assay in rats. Unspecific signs of intoxication in combination with changes in organ weights (adrenal glands, ovaries, testes) at the highest doses tested without histopathological correlates resulted in NOAELs (general toxicity) of 20 mg/kg bw/day (subacute study) or 40 mg/kg bw/day (OECD TG 421) for rats of both sexes, respectively.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 35.3 mg/m³
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 40 mg/kg bw/day
Additional information
In case of Repeated dose toxicity (dermal and inhalation route) dose descriptor are based on extrapolation from oral study.
Justification for classification or non-classification
Based on the test results and according to the EC criteria for classification and labelling requirements for dangerous substances and mixtures the test substance does not have to be classified for repeated dose toxicity.
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