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EC number: 271-802-8 | CAS number: 68608-82-2 A complex combination of hydrocarbons obtained by the alkylation of benzene with ethene. It consists primarily of ethylbiphenyls, diethylbenzenes with lesser amounts of butylbenzenes and polyethylbenzenes.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2a: Reliable with restrictions; acceptable, well- documented study report which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Principles of method if other than guideline:
- Other - Not listed
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Name of test material (as cited in study report): Polyethylbenzene (PEB) Bottoms (CAS No. 6897-43-9)
- Analytical purity: not stated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- At the start of the experiment, animals were 70 days of age and weighed between 129.27 g to 206.32 g. During the study, animal rooms were maintained at an average ambient temperature of 73.6ºF and relative humidity of 55.5%.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- paraffin oil
- Details on exposure:
- Prior to treatment initiation, the backs of all animals were clipped free of hair. Each animal was fitted with an Elizabethan collar to prevent ingestion of test or control substances. The three dose groups consisted of: vehicle control (light paraffin oil) [Group I], diluted low-dose (50%) PEB Bottoms [Group II], high dose (100%) PEB Bottoms [Group III]. The appropriate doses or test control substance were applied topically to the prepared back of 5 test animals per group for a period of 6 hours. Treatment was performed once daily for a total of 5 doses.
- Duration of treatment / exposure:
- Five days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1 and 2 g/kg bw
Basis:
nominal per unit body weight
- No. of animals per sex per dose:
- Five
- Control animals:
- yes, concurrent vehicle
Examinations
- Observations and examinations performed and frequency:
- Animals were observed daily for clinical signs, mortality and moribundity. Dermal reactions were observed and scored twice on the initial dosing day and at the time of residual test substance removal. The Draize Scoring System for evaluating dermal reactions was used for scoring purposes.
Body weights were recorded immediately prior to initial treatment and again at necropsy. - Sacrifice and pathology:
- All animals surviving to the scheduled study termination were sacrificed on Day 8 and gross necropsies on all animals were performed.
- Other examinations:
- Not applicable
- Statistics:
- Mean and standard deviation
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not specified
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- not examined
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- All animals survived to the termination of the study. No mortality occurred as a result of the 5-day repeated dermal application of Polyethylbenzene Bottoms to male and female rats at dose levels of 1.0 g/kg (Group II) and 2.0 g/kg (Group III). Statistical analyses of group mean body weights revealed weight losses among males and females at both the 1.0 and 2.0 g/kg dose levels that were significant at the 99% confidence level.
A yellow brown discoloration of the test site was seen among all animals treated with the test substance. Dermal irritation was observed among animals in Groups II and III. Barely perceptible erythema was observed in the Group II (1.0 g/kg) animals. Erythema (ranging from very slight to well defined) and barely perceptible edema were seen among animals in Group III (2.0 g/kg).
Focal thickening of the skin at the point of application of the test substance was observed in Group III (2.0 g/kg).
Effect levels
- Dose descriptor:
- LOEL
- Effect level:
- 1 000 mg/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- other: Based on Local skin irritation at the sight of application and bodyweight differences
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Not applicable
Applicant's summary and conclusion
- Conclusions:
- Dermal exposure to the test material for 5 daily doses produced signs if skin irritation and also a decrease in bodyweight gain. Due to these effects occuring at both dose levels it is not possible to assign a NOEL. However the effects observed are likely the result of toxicity to the site of dosing rather than systemic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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