Registration Dossier
Registration Dossier
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EC number: 204-623-0 | CAS number: 123-38-6
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Human liver aldehyde dehydrogenase: partial purification and properties
- Author:
- Blair A.H., Bodley F.H
- Year:
- 1 969
- Bibliographic source:
- Canadian journal of biochemistry vol 47
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- extraction of aldehyde dehydrogenase from human liver
- GLP compliance:
- no
Test material
- Reference substance name:
- Propionaldehyde
- EC Number:
- 204-623-0
- EC Name:
- Propionaldehyde
- Cas Number:
- 123-38-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- propanal
- Details on test material:
- - Name of test material (as cited in study report): Propionaldehyde
- Analytical purity: reagent grade
distilled under nitrogen before use
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- human
- Strain:
- other: not applicable
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: not applicable
- Vehicle:
- other: not applicable
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.05, 0.03, 3.0 mM propionaledhyde
- No. of animals per sex per dose / concentration:
- not applicable: in vitro test
- Control animals:
- no
- Positive control reference chemical:
- Acetaldehyde
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- not applicable
- Details on distribution in tissues:
- not applicable
- Details on excretion:
- not applicable
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
The rate of oxidation for propionaldehyde is comparable to acetaldehyde when tested in vitro at substrate concentrations between 0.5 and 3.0 mM using partially purified human liver aldehyde dehydrogenase
Relative rates of oxidation of aldehydes by human liver aldehyde dehydrogenase:
| Aldehyde concentration | |||
| substrate | 0.05 mM | 0.03 mM | 3.0 mM |
| Acetaldehyde | 0.82 | 0.92 | 1.0* |
| Propionaldehyde | 0.90 | 1.0 | 1.1 |
(*: Rate with 3.0 mM acetaldehyde set equal to 1.0 as standard)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
