Registration Dossier
Registration Dossier
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EC number: 201-696-0 | CAS number: 86-74-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In experiments using rat and rabbit, the glucuronide of 3-hydroxycarbazole was demonstrated to be the major metabolite in the urine.
After administration of C14-labeled carbazole to rats, 65% of the radioactivity administered was found in the 3-day urine. After acid hydrolysis of the urine, 55% of the total radioactive dose distributed into an ether extract of the urine. After further purification, 33% of the dose were isolated from the ether extract as 3-hydroxycarbazole. Another 10% of total radioactivity in the ether extract could be attributed to at least two more phenolic carbazole derivatives more polar than 3-hydroxcarbazole (possibly di- and polyhydroxylated carbazoles).The identity of the radioactivity not excreted into the urine (35% of total dose) or remaining in the aqueous phase of urine (10% of total dose) was not elucidated.
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