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Diss Factsheets
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EC number: 425-380-9 | CAS number: 7397-46-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC Commission Directive 2000/32/EC Method B11 OECD Guideline 475 (1997)
- GLP compliance:
- yes
- Type of assay:
- other: in vivo mammalian bone marrow cytogenetic test
Test animals
- Species:
- other: Mouse NMRI BR (SPF)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Corn oil
- No. of animals per sex per dose:
- Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 18 hours
Male: 140 mg/kg; No. of animals: 5; Sacrifice time: 18 hours
Male: 140 mg/kg; No. of animals: 5; Sacrifice time: 36 hours
Male: 70 mg/kg; No. of animals: 5; Sacrifice time: 18 hours
Male: 35 mg/kg; No. of animals: 5; Sacrifice time: 18 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 18 hours
Female: 140 mg/kg; No. of animals: 5; Sacrifice times: 18 hours
Female: 140 mg/kg; No. of animals: 5; Sacrifice times: 36 hours
Female: 70 mg/kg; No. of animals: 5; Sacrifice times: 18 hours
Female: 35 mg/kg; No. of animals: 5; Sacrifice times: 18 hours
Results and discussion
- Additional information on results:
- Doses producing toxicity:
In animals dosed with the test material premature deaths
occurred at and above 175 mg/kg. The two animals dosed with
2000mg/kg died within 15 minutes of dosing, all other
animals dosed with >100mg/kg showed ataxia and tremors at
this time point. Other clinical signs observed at and above
140 mg/kg were as follows: lethargy, hunched posture, pale
skin, rough coat and ptosis.
The test substance demonstrated greater toxicity in males,
thus both sexes were used in the main test.
Adequate evidence of test material toxicity was demonstrated
by the intraperitoneal route; the maximum tolerated dose
was 140 mg/kg
Observations:
Within 45 minutes of dosing all animals dosed with 140mg/kg
of the test substance showed ataxia and tremors. Clinical
signs had resolved in all but three females by 17 hrs post
dosing. One of these animals died at 19 hrs and was replaced
with aa additional dosed animal.The other two animals
survived to sacrifice.
A significant reduction in the Mitotic index (39-41%) was
observed at 35 mg/kg. This was taken to confirm that
systemic absorption had occurred and exposure to the bone
marrow was achieved.
The test material did not cause a statistically significant
or biologically relevant increase in the frequency of cells
with chromosomal aberrations compared to concurrent
controls. No effects of the test substance on the number of
polyploid cells and cells with endoreplicated chromosomes
were observed.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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