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EC number: 429-370-5 | CAS number: 220410-74-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003-02-25 to 2003-05-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP compliant Guideline study. Deficiencies when compared to latest Guideline: - Clinical monitoring: now twice per day - Body weight: now mandatory for day 0 and at least on days 1, 3 and 7 (and weekly thereafter), and at the time of death or euthanasia if exceeding day 1.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- adopted May 12, 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- Version / remarks:
- adopted August 1998
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 429-370-5
- EC Name:
- -
- Cas Number:
- 220410-74-2
- Molecular formula:
- C34H67N3O13
- IUPAC Name:
- tris(1,4-dihydroxy-2,2,6,6-tetramethylpiperidin-1-ium) 2-hydroxypropane-1,2,3-tricarboxylate
- Test material form:
- other: fine white powder
- Details on test material:
- - Identification: FAT 76'042/C
- Description: fine white powder
- Solubility: soluble in water and acetone
- Composition of test material, percentage of components: 94.8 % active ingredient, 3.8 % water, 0.6 % other
- Lot/batch No.: E/PT103
- Expiration date of the lot/batch: August 10, 2003
- Storage: refrigerated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals Inc., Boyertown, PA, USA
- Age at study initiation: 11-12 weeks
- Weight at study initiation: males 321-370 g and females 204-235 g
- Housing: singly in suspended stainless steel caging with mesh floors
- Diet: Purina Rodent Chow #5012, ad libitum
- Water: tap water ad libitum
- Acclimation period: 29 days
ENVIRONMENTAL CONDITIONS
- Temperature: 16-21°C
- Humidity: 38-56%
- Photoperiod: 12 h light / 12 h dark cycle
IN-LIFE DATES: From: 2003-02-26 To:2003-03-12
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Mini-Nose Only inhalation Chamber, ADG Developments LTD
- Exposure chamber volume: approximately 6.7 liters (internal)
- Method of holding animals in test chamber: individually in polycarbonate holding tubes
- Source and rate of air: 28.3 liters per minute (Lpm) of compressed generator air (JUN-AIR)
- Method of conditioning air: Compressed generator air was supplied to the dust generator. An additional 3.3 Lpm of compressed mixing air, supplied using dry filtered air (WELCO), was introduced into the chamber.
- System of generating particulates/aerosols: Test item compressed to 200 lbs/sq by a Carver Lab Press Model C was packed into a DF 183 Wright Dust Container. The container was fitted witth a DF 191 Stainless Steel Cutting Blade, driven by a Dayton Model 4Z538A adiustabte speed motor.
- Method of particle size determination: eight-stage Andersen cascade impactor. Aerodynamic mass median diameter was determined graphically using two-cycle logarithmic probit axes
- Treatment of exhaust air: fed into base unit
- Temperature and humidity in air chamber: 19-21°C and 38-45 %
TEST ATMOSPHERE
- Brief description of analytical method used: gravimetric samples, collected using 25 mm glass fibre filters in a filter holder connected to a vacuum pump. The mass collected was divided by the total volume of air sampled to determine the chamber concentration. Sample airflow were measured using an Omega Flowmeter Model #FMA 5610.
- Samples taken from breathing zone: yes
TEST ATMOSPHERE
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): 3.8 µm / 2.03 - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Gravimetric chamber concentration: 5.08 mg / L.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Individually prior to test substance exposure (initial) and again on days 7 and 14 (termination)
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.08 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- All animals survived exposure to the test atmosphere.
- Clinical signs:
- other: Not noted
- Body weight:
- All animals gained body weight over the 14-day observation period.
- Gross pathology:
- No gross abnormalities were noted.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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