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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

All studies resulted in negative (non-mutagenic or non-clastogenic) outcomes. The in vitro Micronucleus test and the in vitro Unscheduled DNA Synthesis tests did not use extrinsic metabolic activation because intrinsic metabolic activity was demonstrated. 

Data matrix – Analog approach

Target substance

Source substance (1)

 

CHEMICAL NAME

2-methylbutyl acrylate

n-butyl acrylate

 

CAS#

44914-03-6

141-32-2

 

Molecular formula

C8H14O2

C7H12O2

 

Molecular Weight

142.2

128.2

 

PHYSICO-CHEMICAL DATA     

Melting Point

Experimental:

≤ -75 °C

Not available

 

Boiling Point

Experimental:

161.7 °C at 1013hPa

Experimental:

147 °C at 1013hPa

 

Density

Experimental:

0.8886 g/cm3 at 25 °C

Experimental:

0.9 g/cm3 at 20.0 °C

 

Vapour Pressure

Experimental:

1.7 hPa at 20°C

Experimental:

5 hPa at 22.2°C

 

Partition Coefficient (log KOW)

Experimental:

2.9

Experimental:

2.38 (at 25°C)

 

Water Solubility

Experimental:

316 mg/L at 23 °C

Not available

 

MAMMALIAN TOXICITY

Ames Assay

Readacross from source (1):

Non-mutagenic

Experimental:

Non-mutagenic

 

In vivo Chromosome Aberration

in rats via inhalation

Readacross from source (1):

Non-clastogenic

Experimental:

Non-clastogenic

 

In vivo Chromosome Aberration

in hamsters via inhalation

Readacross from source (1):

Non-clastogenic

Experimental:

Non-clastogenic

 

In vitro micronucleus (SHE cells)

Readacross from source (1):

Non-mutagenic

Experimental:

Non-mutagenic

 

In vitro UDS

Readacross from source (1):

Non-mutagenic

Experimental:

Non-mutagenic

 


Short description of key information:
Genetic toxicity studies have been conducted on the source chemical n-butyl acrylate. These results are considered appropriate for the target chemical 2-methylbutyl acrylate.

Ames Assay: Non-mutagenic with and without activation

In vitro Micronucleus Test using SHE cells: Non-mutagenic

In vitro Unscheduled DNA Synthesis using SHE cells: Non-mutagenic

In vivo Chromosome Aberration in Rats via inhalation: Non-clastogenic

In vivo Chromosome Aberration in Hamsters via inhalation: Non-clastogenic

Endpoint Conclusion:

Justification for classification or non-classification

Results did not meet the criteria for classification.