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EC number: 204-004-5 | CAS number: 112-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Steaorylchloride is irritationg to the skin but non-irritating to the eye
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards with acceptable restrictions (limited documentation, e.g. no details about test substance or applied amount of test substance)
- Principles of method if other than guideline:
- White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions.
An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance. In addition, skin tissue from the ear was
tested by wrapping the ear. These results from the ear, however, would not be taken into account for evaluation as they do not represent testing of the dorsal/lateral flank of the back. After the application time, the skin was washed with water which sometimes contained a mild detergent.
The animals were observed 7 to 8 days and skin changes were recorded on working days. Tests used occlusive dressing, in contrast to the semiocclusive dressing specified by the guidelines. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no volume or weight reported. an application site of 2,5 x 2,5 cm was coverd with liquid - Duration of treatment / exposure:
- Experiment 1: 1, 5, or 15 minutes
Experiment 2: 20 h - Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: An aerea of 2,5 x 2.5 cm of the flank was exposed
- Type of wrap if used: occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the exposure time, the skin was washed with 50% Lutrol in water.
- Time after start of exposure: 20 h
SCORING
- see table below - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusive exposure
- Time point:
- other: 24 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- occlusive exposure 20 h
- Time point:
- other: 24 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusive exposure
- Time point:
- other: 24
- Score:
- ca. 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- 20 h occlusive exposure
- Time point:
- other: 24 h
- Score:
- ca. 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Executive summary:
Study meets scientific standards with acceptable restrictions (limited documentation, e.g. no details about test substance or applied amount of test substance). 2 rabbits were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance. After the application time, the skin was washed with water which sometimes contained a mild detergent. The animals were observed 8 days and skin changes were recorded on working days. Marked erythema, slight edema and minimal necrotic effects were obseved afte 20 h occlusive exposure. Marked erythema, slight edema but not any necrotic effects were see after 15 min exposure.
Conclusion
The test substance was graded irritating. Minor necrotic effects after 20 h occlusive exposure were judge to be due to the more stringent test procedure in comparisson to a OECD Guideline study.
Reference
Since irritation data are recommended for a 4 h skin exposition, results of the available 20 h and the 15 min exposition will serve as approximation.
Descriptive scores of the raw data have been converted to Draize numerical scores.Erythema scoring was at the border of the necrotic aerea.
Exposition: |
20 h |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
2 |
1 |
|
2 |
24 h |
2 |
0 |
necrosis |
1 |
48 h |
2 |
1 |
|
2 |
48 h |
2 |
0 |
necrosis |
1 |
72 h |
2 |
1 |
|
2 |
72 h |
1 |
0 |
necrosis |
1 |
8 d |
0 |
0 |
superficial necrosis squamation |
2 |
8 d |
0 |
0 |
necrosis squamation |
mean |
24 - 48 h |
2.0 |
0.5 |
|
|
|
|
|
|
Exposition: |
15 min |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
2 |
1 |
|
2 |
24 h |
2 |
0 |
|
1 |
48 h |
2 |
1 |
|
2 |
48 h |
2 |
0 |
|
1 |
72 h |
2 |
1 |
|
2 |
72 h |
1 |
0 |
|
1 |
8 d |
0 |
0 |
squamation |
2 |
8 d |
0 |
0 |
squamation |
mean |
24 - 72 h |
2.5 |
3.25 |
|
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study is comparable to OECD Guideline 405 with acceptable restrictions (partly limited documentation, e.g. no details about the test substance; 50 μl instead of 100 μl test substance instilled; scoring system not according to OECD405). Study sufficient for evaluation of this endpoint.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- only 50 µl; no washing after 24 h
- Principles of method if other than guideline:
- White Vienna rabbits were used. Usually 50µl or mg of the test substance were applied to the conjunctival sac of one eye of 2 animals. The non- or saline-treated adjacent eye served as a control. The animals were observed several times on the treatment day and up to 7 or 8 days afterwards, and findings were recorded on working days. The eyes were not washed out after 24 hours as specified in OECD Guideline 405.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 µl - Observation period (in vivo):
- study terminated afte 48 h
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
SCORING SYSTEM
see table below
TOOL USED TO ASSESS SCORE
fluorescein at the end of the study - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24-48 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- slight erythema (1), and a minimal/questionable edema was observed 3 h after application. The effects were fully reversible with in 1 day. The study was terminated after negative fluorescein staining 48 h after application
- Other effects:
- Traces of blood were visible 3 h after application in both animals. The finding may be due to attemps of the animals to clean their eyes.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Because of the full reversibility of the minimal effects observed within the first 3 h after application the substance is classified as non- irritating.
- Executive summary:
The study is comparable to OECD Guideline 405 with acceptable restrictions. White Vienna rabbits were used. 50µl of the test substance were applied to the conjunctival sac of one eye of 2 animals. The eyes were not washed out after 24 hours.
No effects were observed 24 h after application
Conclusion
Because no effects were observed 24 h after application the substance is classified as non- irritating.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation was tested using an internal standard method (BASF test). This study meets scientific standards with acceptable restrictions (limited documentation).Whiterabbits were used. 2 animals were treated for 1, 5 and 15 minutes and for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance. Marked erythema, slight edema and superficial necrotic effects were observed after 20 h occlusive exposure.Marked erythema, slight edema but not any necrotic effects were see after 15 min exposure. The test substance was graded irritating. Minor necrotic effects after 20 h occlusive exposure were judge to be due to the more stringent test procedure in comparisson to a OECD Guideline study.
Eye irritation was examined in a study comparable to OECD Guideline 405 with acceptable restrictions (limited documentation, reduced application volume). The study is however sufficient for evaluation of this endpoint. No effects were observed 24 h after application
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Based on the available data a classification concerning skin irritation is warranted: Skin Irrit. Cat. 2 according to Annex I of Regulation EC/1272/2008 (CLP). The substance is non irritating to the eyes.
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