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EC number: 700-414-8 | CAS number: 23328-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2 - 3 August 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 30 August 2005 Date of Signature: 21 November 2005
- Type of distribution:
- other: cascade impactor method
Test material
- Reference substance name:
- trimethyl[3-(octadecyloxy)propyl]azanium chloride
- EC Number:
- 700-414-8
- Cas Number:
- 23328-71-4
- Molecular formula:
- C24H52ClNO
- IUPAC Name:
- trimethyl[3-(octadecyloxy)propyl]azanium chloride
- Reference substance name:
- 1-Propanaminium, N,N,N-trimethyl-3-(octadecyloxy)-, chloride
- IUPAC Name:
- 1-Propanaminium, N,N,N-trimethyl-3-(octadecyloxy)-, chloride
- Details on test material:
- - Name of test material (as cited in study report): 3-Octadecyloxypropyl-N,N,N-trimethylammonium chloride
- Molecular formula (if other than submission substance): Not applicable
- Molecular weight (if other than submission substance): Not applicable
- Smiles notation (if other than submission substance): Not applicable
- InChl (if other than submission substance): Not applicable
- Structural formula attached as image file (if other than submission substance): Not applicable
- Substance type: white solid
- Physical state: solid
- Analytical purity: Not reported
- Impurities (identity and concentrations): Not reported
- Composition of test material, percentage of components: Not reported
- Isomers composition: Not reported
- Purity test date: Not reported
- Lot/batch No.: Exp. I-070518
- Expiration date of the lot/batch: Not reported
- Radiochemical purity (if radiolabelling): Not applicable
- Specific activity (if radiolabelling): Not applicable
- Locations of the label (if radiolabelling): Not applicable
- Expiration date of radiochemical substance (if radiolabelling): Not applicable
- Stability under test conditions: Not reported.
- Storage condition of test material: room temperature in the dark.
- Other: Not reported.
Constituent 1
Constituent 2
Results and discussion
Particle size
- Percentile:
- D50
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
Particle size distribution at different passagesopen allclose all
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- 18.6 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- 0.404 %
- No.:
- #3
- Size:
- < 5.5 µm
- Distribution:
- 0.083 %
Any other information on results incl. tables
Screening test (sieve method)
The results of the sieving procedure are shown in Table 2.
Table 2
Sieve aperture size (µm) |
100 |
Mass of test material transferred to sieve (g) |
15.77 |
Mass of test material passed through sieve (g) |
2.94 |
Test material less than sieve aperture size (%) |
18.6 |
Definitive test (cascade impactor method)
Determination 1
The results of the cascade impactor method are shown in Table 3.
Table 3 Determination 1
Cup Number |
ParticleCollected (µm) |
Cup Masses (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
1 |
>10.0 |
86.1377 |
88.7089 |
2.5712 |
2 |
5.5 - 10.0 |
85.4510 |
85.4536 |
0.0026 |
3 |
2.4 - 5.5 |
85.9210 |
85.9215 |
0.0005 |
4 |
1.61 - 2.4 |
85.5999 |
85.6000 |
0.0001 |
5 |
0.307 - 1.61 |
85.7909 |
85.7910 |
0.0001 |
Filter |
<0.307 |
75.1802 |
75.1802 |
0 |
Amount of test material found in
artificial throat: 0.61 g.
Total amount of test material recovered from impactor cups, filter and
artificial throat: 3.1845 g.
The cumulative amounts found for the individual particle size cut-points (µm) are shown in Table 4.
Table 4 Determination 1
Cup Number |
Particle Size Cut-points (µm) |
Cumulative Mass of Test Material (g) |
Cumulative Amount of Test Material (%) |
2 |
10.0 |
0.0033 |
0.104 |
3 |
5.5 |
0.0007 |
2.20 x 10-2 |
4 |
2.4 |
0.0002 |
6.28 x 10-3 |
5 |
1.61 |
0.0001 |
3.14 x 10-3 |
Filter |
0.307 |
0 |
0 |
Determination 2
The results of the cascade impactor method are shown in Table 5.
Table 5 Determination 2
Cup Number |
ParticleCollected (µm) |
Cup Masses (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
1 |
>10.0 |
86.1380 |
88.8016 |
2.6636 |
2 |
5.5 - 10.0 |
85.4513 |
85.4694 |
0.0181 |
3 |
2.4 - 5.5 |
85.9212 |
85.9236 |
0.0024 |
4 |
1.61 - 2.4 |
85.6003 |
85.6008 |
0.0005 |
5 |
0.307 - 1.61 |
85.7910 |
85.7919 |
0.0009 |
Filter |
<0.307 |
75.1796 |
75.1799 |
0.0003 |
Amount of test material found in
artificial throat: 0.43 g.
Total amount of test material recovered from impactor cups, filter and
artificial throat: 3.1158 g.
The cumulative amounts found for the individual particle size cut-points (µm) are shown Table 6.
Table 6 Determination 2
Cup Number |
Particle Size Cut-points (µm) |
Cumulative Mass of Test Material (g) |
Cumulative Amount of Test Material (%) |
2 |
10.0 |
0.0222 |
0.712 |
3 |
5.5 |
0.0041 |
0.132 |
4 |
2.4 |
0.0017 |
5.46 x 10-2 |
5 |
1.61 |
0.0012 |
3.85 x 10-2 |
Filter |
0.307 |
0.0003 |
9.63 x 10-3 |
Determination 3
The results of the cascade impactor method are shown in Table 7.
Table 7 Determination 3
Cup Number |
ParticleCollected (µm) |
Cup Masses (g) |
||
Pre-sampling |
Post-sampling |
Difference |
||
1 |
>10.0 |
86.1403 |
89.0288 |
2.8885 |
2 |
5.5 - 10.0 |
85.4519 |
85.4615 |
0.0096 |
3 |
2.4 - 5.5 |
85.9217 |
85.9229 |
0.0012 |
4 |
1.61 - 2.4 |
85.5999 |
85.5999 |
0 |
5 |
0.307 - 1.61 |
85.7909 |
85.7921 |
0.0012 |
Filter |
<0.307 |
75.181 |
75.1816 |
0.0006 |
Amount of test material found in
artificial throat: 0.29 g.
Total amount of test material recovered from impactor cups, filter and
artificial throat: 3.1911 g.
The cumulative amounts found for the individual particle size cut-points (µm) are shown in Table 8.
Table 8 Determination 3
Cup Number |
Particle Size Cut-points (µm) |
Cumulative Mass of Test Material (g) |
Cumulative Amount of Test Material (%) |
2 |
10.0 |
0.0126 |
0.395 |
3 |
5.5 |
0.0030 |
9.40 x 10-2 |
4 |
2.4 |
0.0018 |
5.64 x 10-2 |
5 |
1.61 |
0.0018 |
5.64 x 10-2 |
Filter |
0.307 |
0.0006 |
1.88 x 10-2 |
The overall cumulative amounts of test material with a particle size less than 10.0 µm (%) from Determinations 1 to 3 are shown in Table 9.
Table 9
Determination |
Cumulative Amount of Test Material Less Than 10.0 µm (%) |
Mean Cumulative Amount of Test Material Less Than 10.0 µm (%) |
1 |
0.104 |
0.404 |
2 |
0.712 |
|
3 |
0.395 |
The overall cumulative amounts of test material with a particle size less than 5.5 µm (%) from Determinations 1 to 3 are shown in Table 10.
Table 10
Determination |
Cumulative Amount of Test Material Less Than 5.5 µm (%) |
Mean Cumulative Amount of Test Material Less Than 5.5 µm (%) |
1 |
2.20 x 10-2 |
8.27 x 10-2 |
2 |
0.132 |
|
3 |
9.40 x 10-2 |
Discussion
Too few particles were of a size less than 10.0 µm to allow accurate assessment of mass median aerodynamic diameter.
Representative sampling was ensured by rolling the sample container for approximately 10 minutes and sampling from the top, middle and bottom prior to definitive testing.
The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
Applicant's summary and conclusion
- Conclusions:
- Particle size data acquired for the test material are;
Particle size data acquired for the test material are shown (Sieve method); 18.6%;
Proportion of test material having a thoracic particle size less than 10.0 µm (cascade impactor); 0.404%;and
Proportion of test material having a respirable particle size less than 5.5 µm (cascade impactor); 8.27 x 1.00E-02%. - Executive summary:
- Particle size data have been acquired
using a procedure designed to comply with the European Commission
technical guidance document 'Particle Size Distribution, Fibre Length and
Diameter Distribution' (June 1996), which satisfies the requirements of
OECD Guideline 110. The results are as follows:
Measurement
Method
Result
Proportion of test material having an inhalable particle size less than 100 µm
Sieve
18.6%
Proportion of test material having a thoracic particle size less than 10.0 µm
Cascade Impactor
0.404%
Proportion of test material having a respirable particle size less than 5.5 µm
Cascade Impactor
8.27 x 10-2%
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