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Diss Factsheets
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EC number: 208-063-8 | CAS number: 507-09-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
The acute oral LD50 of THIOACETIC ACID was comprised between 200 and 350mg/kg, in female rats. Hypoactivity or sedation, piloerection, dyspnea, lateral recumbency, tonic-clonic convulsions and hypersalivation were the clinical signs observed prior to death. The dermal LD0 of THIOACETIC ACID is equal to or higher than 2000 mg/kg in rats. No signs of toxicity were observed at this dose.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 200 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Oral route
The acute oral toxicity of the THIOACETIC ACID was evaluated in rats according to OECD (No. 401, 24th February 1987) and EC (92/69/EEC, B.l, 31st July 1992) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. The test substance was administered by oral route (gavage) to groups of five male or five female fasted Sprague-Dawley rats. The test substance was prepared in corn oil and administered to the animals under a volume of 10 ml/kg. The study design was as follows:
Dose (mg/kg) |
Vehicle |
Volume (ml/kg) |
Male |
Female |
200 |
corn oil |
10 |
|
5 |
350 |
corn oil |
10 |
|
5 |
500 |
corn oil |
10 |
|
5 |
1000 |
corn oil |
10 |
5 |
|
Clinical signs, mortality and body weight gain were checked for a period of up to 14 days following the single administration of the test substance. All animals were subjected to necropsy.
At the 200 mg/kg dose-level, no clinical signs and no mortality were recorded. At the 350, 500 and 1000 mg/kg dose-levels, all animals died within 24 hours following treatment. Hypoactivity or sedation, piloerection, dyspnea, lateral recumbency, tonic-clonic convulsions and hypersalivation were the clinical signs observed prior to death. The body weight gain of the surviving animals given 200 mg/kg was not affected by treatment with the test substance. At necropsy, a whitish coloration of the stomach and intestines was noted in the animals given 1000 mg/kg. No apparent abnormalities were observed in the other animals. The oral LD50 of the test substance THIOACETIC ACID is comprised between 200 and 350 mg/kg, in female rats.
Dermal route
The acute dermal toxicity of THIOACETIC ACID was evaluated in rats according to OECD (No. 402, 24th February 1987) and EC (92/69/EEC, B.3, 31 st July 1992) guidelines. The study was conducted in compliance with the principles of Good Laboratory Practice Regulations. The test substance was applied to the skin of one group of ten Sprague-Dawley rats (five males and five females). The application was performed with the undiluted test substance at the dose of 2000 mg/kg, taking into consideration that its specific gravity was 1.064. The test site was then covered by a semi-occlusive dressing for 24 hours. Clinical signs, mortality and body weight gain were checked for a period of 14 days following the single application of the test substance.All animals were subjected to necropsy.No death occurred at 2000 mg/kg. The general behaviour and overall body weight gain of the animals were not affected by treatment with the test substance. No cutaneous reactions were observed.No apparent abnormalities were observed at necropsy in all the animals.Under these experimental conditions, the dermal LD0of THIOACETIC ACID is equal to or higher than 2000 mg/kg in rats. No signs of toxicity were observed at this dose.
Justification for selection of acute toxicity – oral endpoint
Key study
Justification for selection of acute toxicity – dermal endpoint
Key study
Justification for classification or non-classification
Acute oral toxicity:
The oral LD50of thioacetic acid was higher than 200 mg/kg and lower than 350 mg/kg in rats. In accordance with Regulation (EC) No 1272/2008, thioacetic acid shall be classified as Acute Tox. 3 (Hazard statement: H301; Toxic if swallowed) and in accordance with Annex VI of Commission Directive 2001/59/EC, tioacetic acid shall be classified as being harmful if swallowed (R22).
Acute inhalation toxicity:
Data lacking.
Acute dermal toxicity:
The percutaneous LD0of ioacetic acid was greater than 2000 mg/kg in rats. On this basis and in accordance with Regulation (EC) No 1272/2008 and in accordance with Annex VI of Commission Directive 2001/59/EC, thioacetic acid shall not be classified with respect to acute dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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