Dinoseb

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

Not reported

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: No guideline followed. Atypical species of animal used.

Data source

Reference

Reference Type:

publication

Title:

Toxicity, Uptake, and Elimination of the Herbicides Alachlor and Dinoseb in Freshwater Fish

Author:

Call. D.J, et al

Year:

1984

Bibliographic source:

J. Environ. Qual., Vol 13, no. , 1984 pp. 493 - 498

Materials and methods

Objective of study:

metabolism

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

in vivo metabolism study

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Dinoseb

EC Number:

201-861-7

EC Name:

Dinoseb

Cas Number:

88-85-7

Molecular formula:

C10H12N2O5

IUPAC Name:

dinoseb

Radiolabelling:

yes

Test animals

Species:

other: fish

Strain:

other: Pimephales promelas & Salmo gairdneri

Sex:

not specified

Results and discussion

Any other information on results incl. tables

Dinoseb was readily eliminated by trout as both parent compound and as metabolites. Ninety percent of the herbicide injected into trout was recovered in the water within 24 h, of which 50% appeared to be parent compound by TLC. At least two polar metabolites and one or two metabolites less polar than dinoseb were present in the water. A similar metabolite profile was observed in bile, except that no parent compound was present. Insufficient quantities of metabolites were available for generation of mass spectra and GC/MS characterization. Mammalian studies have shown that dinoseb is readily metabolized.

Applicant's summary and conclusion

Conclusions:

Interpretation of results: low bioaccumulation potential based on study results
Dinoseb is not highly bioconcentrated in fish tissue, and small amounts that may accumulate are readily eliminated when the exposure ends.

Executive summary:

In a series of studies investigating the acute toxicity, effects to early-life stages as well as uptake and elimination of dinoseb, rainbow trout weighing 100 to 150 g were injected with 37 kBq of 14C-labelled herbicide after exposure for 4 to 5 days to low levels of unlabelled compound. Fish were sacrificed after 24 hours.

Dinoseb was readily eliminated by trout as both the parent compound and as metabolites. Ninety per cent of the herbicide injected into trout was recovered in the water within 24 hrs, of which 50% appeared to be parent compound by TLC. At least two polar metabolites and one or two metabolites less polar than dinoseb were present in the water. A similar metabolite profile was observed in bile, except that no parent compound was present. Insufficient quantities of metabolites were available for generation of mass spectra and GC/MS characterization.