Registration Dossier
Registration Dossier
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EC number: 200-935-6 | CAS number: 76-12-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- no data
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE
- Author:
- American Conference of Industrial Hygienists (ACGIH)
- Year:
- 2 008
- Bibliographic source:
- 1,1,2,2-Tetrachloro-1,2-Difluoroethane: TLV® Chemical Substances 7th Edition Documentation ACGIH® Publication
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 947
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 963
Materials and methods
- Principles of method if other than guideline:
- not documented
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetrachloro-1,2-difluoroethane
- EC Number:
- 200-935-6
- EC Name:
- Tetrachloro-1,2-difluoroethane
- Cas Number:
- 76-12-0
- Molecular formula:
- C2Cl4F2
- IUPAC Name:
- 1,1,2,2-tetrachloro-1,2-difluoroethane
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report):
1,1,2,2-tetrachloro-1,2-difluoroethane, CFC-112; 1,2-DIfluoro-1,1,2,2-tetrachloroethane; Halocarbon 112; Refrigerant 112
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Results and discussion
In vivo
Results
- Remarks on result:
- other: only slight irritation was seen when 1,1,2,2-tetrachloro-1,2-difluoroethane was placed in the rabbit eye.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for Serious Eye Damage/Eye Irritation.
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.
ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
According to the ACGIH sheet, only slight irritation was seen when 1,1,2,2-tetrachloro-1,2-difluoroethane was placed in the rabbit eye. (DuPont Company, 1947, 1963).
According to Regulation (EC) No. 1272/2008, 1,1,2,2 -tetrachloro-1,2-difluoroethane does not meet the classification criteria for Serious Eye Damage/Eye Irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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