Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 460-100-9 | CAS number: 342573-75-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 402)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- - Temporary deviations from the minimum level of relative humidity occurred. However, laboratory historical data do not indicate an effect of the deviations
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- Physical apprearance: Light yellow viscous liquid
- Batch: 99/484
- Storage: RT in the dark
- Specific gravity: 1.23
- Purity: 99% (HPLC)
- Stability under storage conditions: not indicated
- Expiry date: 10 june 2005 (allocated by NOTOX, 1 year after receipt of the test substance)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar strain, Crl:WI (outbred, SPF-quality)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Charles River Deutschland, Germany
- Age at study initiation: approx. 10 weeks
- Weight at study initiation: Body weight variation did not exceed +/- 20% of the sex mean
- Housing: no data
- Diet: ad libitum; standard pelleted laboratory animal diet (from Altromin (code VRF 1), Lage, Germany
- Water: ad libitum; tap water
- Acclimation period: 5 days, A health inspection was performed prior to cornmencement of treatment, to ensure that the animals were in a good state of health. Special attention was paid to the skin to be treated, which was intact and free from any abnormality.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.3-21.3
- Humidity (%): 25-68
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: undiluted
- Details on dermal exposure:
- TEST SITE
- Clipping: One day before exposure (day -1) an area of approximately 5x7 cm on the back of the animal
- Area of exposure: 10% of total body surface; approx 25 cm2 in males and 18 cm2 in females
- % coverage: no data
- Type of wrap if used: The test substance was held in contact with the skin with a dressing, consisting of a surgical gauze (Surgy 1 D); successively covered with aluminium foil and Coban elastic bandage. A piece of Micropore tape' was additionally used for fixation of the bandages in females only.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.63 ml/kg bw
- Concentration (if solution): undiluted
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg (1.63 ml/kg)
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Frequency of application: single dosage, on day 1
- Duration of observation period following administration: 14 days
- Mortality: Checked twice daily.
- Frequency of observations: clinical signs; at periodic intervals on the day of dosing (day 1) and once daily thereafter, until day 15. The time of onset, degree and duration were recorded and the symptoms graded according to fixed scales: Maximum grade 4: grading slight (I) to very severe (4) Maximum grade 3: grading slight (I) to severe (3) Maximum grade 1: presence is scored (1).
- Frequency of weighing: Days 1 (pre-administration), 8 and 15 days
- Necropsy of survivors performed: at the end of the observation period, all animals were sacrificed by asphyxiation using an oxygen/carbon dioxide procedure and subjected to necropsy. Descriptions of all internal macroscopic abnormalities were recorded.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No mortality occured
- Mortality:
- No mortality occured
- Clinical signs:
- other: Flat and/or hunched posture, chromodacryorrhoea, lethargy and/or ptosis were shown by most animals on days 1 and/or 2. Scales were seen in the treated skin-area of one male and two females between days 3 and 9.
- Gross pathology:
- No test substance related abnormalities were found at macroscopic post mortem examination of the animals. A reduced size of the testes and epididymis was noted in one animal, which is occasionally noted among rats of this age and strain and was therefore considered not toxicologically significant.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Although ECHA is providing a lot of online material in your language, part of this page is only in English. More about ECHA’s multilingual practice.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
the-echa-website-uses-cookies
find-out-more-on how-we-use-cookies