Registration Dossier
Registration Dossier
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EC number: 204-282-8 | CAS number: 118-88-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- DPIM: AKQ000
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials) : Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.: , 1972, 183.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : XT6320000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); 85JCAE "Prehled Prumyslove Toxikologie;Organicke Latky," Marhold, J.,Prague,Czechoslovakia, Avicenum,1986 Volume(issue)/page/year: -1054,1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from SAX and RTECS
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-aminotoluene-3-sulphonic acid
- EC Number:
- 201-831-3
- EC Name:
- 4-aminotoluene-3-sulphonic acid
- Cas Number:
- 88-44-8
- IUPAC Name:
- 2-amino-5-methylbenzenesulfonic acid
- Details on test material:
- Name of the test material: 4-aminotoluene-3-sulphonic acid
Molecular formula: C7H9NO3S
Substance Type: Organic
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 hours
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks on result:
- other: 500mg/24 hrs = Moderate irritation
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance 4-aminotoluene-3-sulphonic acid was found to be moderately irritating to the eye of rabbit at dose concentration of 500 mg/24H.
- Executive summary:
The substance 4-aminotoluene-3-sulphonic acid was found to be moderately irritating to the eye of rabbit at dose concentration of 500 mg/24H. Since the read across is only 80% similar to the target chemical so we cannot confirm that the target chemical have a property of eye irritation.
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