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EC number: 616-291-8 | CAS number: 76114-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-03-18 to 1997-04-01
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented GLP based study according to standard procedure guideline
Data source
Reference
- Reference Type:
- other:
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- Version / remarks:
- (40 CFR Part 798.1100 Toxic Substances Control Act, Health Effects Testing Guidelines- Subpart B)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-propynyl-butylcarbamate
- EC Number:
- 616-291-8
- Cas Number:
- 76114-73-3
- Molecular formula:
- C8H13NO2
- IUPAC Name:
- 2-propynyl-butylcarbamate
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): only common name based on sponsor informaion is given, equivalent to:
Chemical name: Carbarmic acid, N-butyl-,2-propyn-1-yl ester
CAS: 76114-73-3
- Analytical purity: no data available
- Impurities (identity and concentrations): no data available
- Lot/batch No.: no data available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Davidson Mill Breeding Labs in Jamesburg, NJ
- Age at study initiation:no data
- Weight at study initiation:2.00 - 2.28 kg
- Fasting period before study:no
- Housing:stainless steel cages with indirect bedding
- Diet: Lab Diet Certified Rabbit Diet 5322 ad libitum
- Water: ad libitum
- Acclimation period: six days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 65 to 75
- Humidity: was monitored
- Photoperiod: 12 hour light/dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure:mid-dorsal area of the trunk, between scalpulae and pelvis
- % coverage: 10%
- Type of wrap if used: porous gauze dressing and non-irritating tape, entire trunk was encased in impermeable plastic wrap fixed with adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gently with water
- Time after start of exposure: 14 days
TEST MATERIAL
- Amount(s) applied: 2000 mg/kg of animal body weig
- For solids, paste formed: no - Duration of exposure:
- 24h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 1,3,6 and 24 hours after treatment start and daily thereafter for a total of 14 days, dermal observations were recorded at 24 h
- Frequency of weighing: at day7 and terminally
- Necropsy of survivors performed: yes (all animals)
- Other examinations performed: clinical signs, body weight, histopathology
- Sacrificing: by intravenous injection of pentobarbital sodium - Statistics:
- none, as no effects have been observed
Results and discussion
- Preliminary study:
- none
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: at limit dose of 2000 mg/kg bw no toxic effects were detectable
- Mortality:
- No dead rabbits were observed.
- Clinical signs:
- other: There were no clinical signs or dermal findings during the study.
- Gross pathology:
- There were no gross necropsy findings for any examined tissues.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to the authors of the study report, Propargyl-N-butylcarbamat was interpreted to have no dermal toxicity.
- Executive summary:
The acute dermal toxicity of Propargyl-N-butylcarbamat
was determined using rabbits according to a standard test guideline. The limit dose of 2000 mg/kg bw was used for the test. At this limit dose, no deaths, clinical signs, dermal findings, or significant body weight changes have been observed. Hence, the LD50 value was found to be greater than 2000 mg/kg bw.
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