Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-350-6 | CAS number: 57-83-0
Endpoint summary
Administrative data
Description of key information
Only limited information is available concerning acute toxicity of Progesterone. On basis of the low acute toxicity of progesterone after single parenteral administration and the known oral LD50 values for this group of steroidal compounds no risk of acute poisoning has to be assumed after single uptake of progesterone.
Key value for chemical safety assessment
Additional information
Animal Data
Test system |
Substance |
Application |
Test concentration |
Toxicity |
Reference |
Rat |
|
Intraperitoneal |
|
LD50=327 mg/kg |
Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan), vol -, pg 1183, 1995 |
Mouse |
|
Intravenous |
|
LDLo=100 mg/kg Convulsions or effect on seizure; ataxia dyspnea
|
Journal of Medicinal Chemistry, American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-, vol 11, pg 117, 1968 |
Rat |
|
Intraperitoneal |
1 mg/kg
|
TDLo Endocrine (estrogenic) |
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-, vol 92, pg 368, 1988. |
Rat |
|
Intraperitoneal |
16 mg/kg
|
TDLo Behavioral (general anesthetic) |
Clinical Pharmacology and Therapeutics. American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-, vol 14, pg 727, 1976 |
Rat |
|
Intraperitoneal |
20 mg/kg
|
TDLo Behavioral (alteration of classical conditioning) |
Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-, vol 29, pg 1597, 2004. |
Rat |
|
Subcutaneous |
2.5 mg/kg |
TDLo Behavioral (Changes in psychophysiological tests); effects on fertility (mating performance) |
Hormones and Behavior. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-, vol 49, pg 105, 2006 |
Rat |
|
Intramuscular |
1 mg/kg |
TDLo Kidney, ureter, bladder (other changes in urine composition); nutritional and gross metabolic (changes in Na) |
European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-, vol 454, pg 131, 2002 |
Mouse |
|
Intraperitoneal |
5 mg/kg |
TDLo Behavioral (change in motor activity, alteration of classical conditioning) |
Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-, vol 23, pg 276, 2000 |
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
