Registration Dossier
Registration Dossier
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EC number: 214-240-0 | CAS number: 1116-70-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Data source
Materials and methods
Results and discussion
Any other information on results incl. tables
Aluminum alkyls are highly reactive substances both in air and in contact to water, causing explosive or flammable situations as explained below. They are known to cause burns to the skin and eyes. Thus, this test is technically not feasible to conduct and is scientifically unjustified.
Most of the chemistry of organoaluminum compounds can be explained in terms of the Lewis acidity of organoaluminum monomers, directly related to the tendency of the aluminum atom to build up an octet of electrons. Reactions of these substances are explosive. The trialkyl aluminums are highly reactive towards oxidising agents including molecular oxygen, thus, the fast reactions in air.
Reactions with Oxygen (air)
R3Al + O2¿ Al2O3 + H2O + CO2
This reaction is vigorous and will generally cause the material to ignite resulting in a fire difficult to extinguish.
Reactions with Water:
R3Al + H2O ¿ Al2(OH)3+ RH + Heat
This reaction is even more violent than those with oxygen. The reaction causes flammable gases that are easily ignited by the fire already created by the organoaluminum compound with water.
Thus, exposure of mammalian species to aluminum alkyls would not generate meaningful data, and no acute oral toxicity study is required for this substance.
Applicant's summary and conclusion
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