Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Meets the criteria for classification as Reliable without restriction according to Klimisch et al (1997)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Annex V, C7
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Total recovery of test substance (in %)open allclose all
% Recovery:
100
pH:
4
Temp.:
50 °C
Duration:
>= 5 d
% Recovery:
21.5
pH:
7
Temp.:
50 °C
Duration:
>= 5 d
% Recovery:
24.1
pH:
9
Temp.:
50 °C
Duration:
>= 5 d

Any other information on results incl. tables

Under the test conditions the substance was found to undergo significant hydrolysis at pH4 (100%), pH 7 (21%) and pH 9
(24%) after 5 days at 50 deg C. The results indicate that at 25 deg. C the half life will be between 1 day and 1 year at pH 4, 7, and 9.

Applicant's summary and conclusion