Registration Dossier
Registration Dossier
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EC number: 218-561-7 | CAS number: 2182-55-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1964-06-16 to 1964-06-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-standard study. Non-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- BASF-test
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- (vinyloxy)cyclohexane
- EC Number:
- 218-561-7
- EC Name:
- (vinyloxy)cyclohexane
- Cas Number:
- 2182-55-0
- Molecular formula:
- C8H14O
- IUPAC Name:
- (ethenyloxy)cyclohexane
- Test material form:
- other: colorless liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Hannover
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age: young adult
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aqueous emulsion with tragacanth
- Details on exposure:
- Form of administration: 1 - 2% aqueous emulsion with tragacanth
Route of aciministration: Intraperitoneal - Doses:
- 1600, 200, 160, 125, 100, 50 mg/kg bw
- No. of animals per sex per dose:
- 10 (5 males and 5 females) per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 0.11 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponding to a LD50 of 98 mg/kg bw assuming a density of 0.89 g/mL of the test item
- Mortality:
- After 14 days observation period, the dead rate was as follows:
1600 mg/kg bw: 10/10
200 mg/kg bw: 7/10
160 mg/kg bw: 8/10
125 mg/kg bw: 7/10
100 mg/kg bw: 1/10
50 mg/kg bw: 2/10 - Clinical signs:
- Staggering, dyspnea and narcosis; convulsions and late deaths
- Body weight:
- No data
- Gross pathology:
- No abnormalities detected
- Other findings:
- No data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
