Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Following accepted OECD procedures, limit test
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Details on test material:
Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
4.3 µm

Test animals

Species:
other: Rat, Crl:CD(SD)

Administration / exposure

Vehicle:
other: None
Details on inhalation exposure:
Nose only
Duration of exposure:
4 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 2.1 mg/L air
Exp. duration:
4 h
Mortality:
Male: 2.1 mg/L; Number of animals: 5; Number of deaths: 0
Female: 2.1 mg/L; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Immediately after exposure, one male showed transient labored breathing, and one female showed a transient abnormal hindlimb gait. The labored breathing was likely due to the dust exposure while the abnormal g
Gross pathology:
Effects on organs:
None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU