4(3H)-Pyrimidinone, 2-ethoxy-6-hydroxy-

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Not reported

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2003

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Particle size analysis was performed using image analysis. Analysis of a sample was performed using a Coulter Rapidview 5X automated image analysis system that was equipped with a 1 mm flow cell.

GLP compliance:

not specified

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

2-ethoxy-6-hydroxy-3,4-dihydropyrimidin-4-one

EC Number:

612-185-0

Cas Number:

61636-08-6

Molecular formula:

C6H8 N2 O3

IUPAC Name:

2-ethoxy-6-hydroxy-3,4-dihydropyrimidin-4-one

Details on test material:

- Name of test material (as cited in study report): DHEP
- Physical state: solid

Results and discussion

Particle size

Percentile:

D50

Remarks on result:

other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.

Any other information on results incl. tables

Table 1 Summary Data

Distribution Type	D10 (µm)	D25 (µm)	D50 (µm)	D75 (µm)	D90 (µm)
Surface	15.4	25.4	38.6	54.8	68.2
Volume	25.2	35.6	50.2	64.4	75.1

 

Table 2 Rapidview 5X Tabular Data

Diameter (micron)	Sample Sieved - <63 µm
	Surface (%)	Cumulative Surface (%)	Volume (%)	Cumulative Volume (%)
5.34	0.47	0.47	0.06	0.06
5.94	0.46	0.94	0.07	0.13
6.62	0.72	1.66	0.12	0.25
7.38	0.72	2.38	0.13	0.38
8.22	1.16	3.54	0.23	0.61
9.15	0.95	4.48	0.21	0.82
10.20	0.91	5.39	0.23	1.05
11.36	1.22	6.61	0.34	1.39
12.65	1.24	7.85	0.38	1.78
14.10	1.50	9.35	0.52	2.30
15.70	1.92	11.27	0.74	3.04
17.49	2.39	13.65	1.03	4.06
19.48	3.12	16.77	1.49	5.56
21.71	3.61	20.38	1.92	7.48
24.18	4.69	25.07	2.79	10.27
26.94	5.57	30.65	3.69	13.95
30.01	6.37	37.02	4.70	18.65
33.42	7.06	44.08	5.80	24.45
37.23	7.09	51.17	6.49	30.94
41.48	7.47	58.65	7.61	38.55
46.21	7.64	66.29	8.67	47.22
51.47	8.05	74.33	10.18	57.40
57.34	7.92	82.26	11.16	68.56
63.87	7.06	89.31	11.07	79.63
71.15	5.88	95.19	10.27	89.91
79.26	2.97	98.16	5.78	95.68
88.30	1.00	99.16	2.17	97.85
98.36	0.58	99.74	1.40	99.25
109.57	0.14	99.88	0.39	99.64
122.06	0.12	100.0	0.36	100.0

Applicant's summary and conclusion

Conclusions:

The volume distribution of the test material was: D10: 25.2 µm; D25: 35.6 µm; D50: 50.2 µm; D75: 64.4 µm; D90: 75.1 µm.

Executive summary:

Particle size analysis was performed using image analysis. Analysis of the sample was performed using a Coulter Rapidview 5X automated image analysis system that was equipped with a 1 mm flow cell.

A sample was fractionated using a ROTAP fitted with a 270 mesh (63 micron) sieve. The sieving time for complete fractionation of a 50 g sample was established by measuring the increase in weight of the -270 mesh fraction at 5 minute intervals during the sieving operation. Complete fractionation was assumed when a 5 minute increment sieving time did not cause the weight to change by more than 1 %. The sieving time was set at 15 minutes. The sample (264 g) was split into 5 fractions and each fraction was sieved separately.

The volume distribution of the test material was: D10: 25.2 µm; D25: 35.6 µm; D50: 50.2 µm; D75: 64.4 µm; D90: 75.1 µm.