Registration Dossier
Registration Dossier
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EC number: 907-241-9 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- study performed prior to implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chlorodecane; 1-chlorododecane
- EC Number:
- 907-241-9
- Molecular formula:
- C10H21Cl and C12H25Cl
- IUPAC Name:
- 1-chlorodecane; 1-chlorododecane
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 6-8 weeks
- Weight at study initiation: males 157-202 g, females 152-192 g
- Fasting period before study: overnight
- Housing: 5 animals/cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 2°C
- Humidity (%): 55% +/- 10%
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 31.08.1981 To: 17.12.1981
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- Single oral intubation via gavage to animals fasted overnight.
A dilution of the test compound was prepared with the help of a homogenizer (Ultra-Turrax) and kept stable during treatment with a magnetic stirrer. In the doses above 5000 mg/kg bw the test item was applied as a concentrate. - Doses:
- 500, 3000, 5000, 10000 and 20000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at 1, 2, 3, 5 and 24 h after dosing and once daily thereafter
- Frequency of weighing: day 0 (prior to dosing), day 7 and day 14
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- During the study period no mortality was observed.
- Clinical signs:
- other: The main symptoms observed were: sedation, dyspnoea, exophthalmos, curved position, diarrhoea and ruffled fur.
- Gross pathology:
- No pathological organ changes were observed.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The acute oral LD50 of the test item in rats of both sexes observed over a period of 14 days was estimated to be greater than 20.000 mg/kg bw.
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