Registration Dossier
Registration Dossier
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EC number: 200-522-0 | CAS number: 61-90-5
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
Description of key information
99.45% of the particles in the sample have a particle size > 100 µm. The remaining 0.55% has a particle size in the inhalable region, i.e. 10-100 µm. No respirable or thoracic particles are present.
Additional information
The particle size distribution of a sample of L-leucine was assessed using a combination of a sieving and a SEM experiment.
In the sieving experiment, 97.83% of the mass was found to have a particle size > 100 µm.
The sieve fraction < 100 µm was subsequently subjected to SEM analysis and the mass fraction was calculated based on the cubical volume method. 74.58% of the particles in this fraction showed a mean particle size > 100 µm when calculated via this method. The aspect ratio for these particles is > 1, i.e. the particles are long and thin, allowing them to pass through the sieve.
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