Registration Dossier
Registration Dossier
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EC number: 211-077-7 | CAS number: 629-15-2
Endpoint summary
Administrative data
Description of key information
Additional information
Acute tests evaluating the toxicity of ethylene diformate (CAS 629-15-2) to aquatic organisms from two different trophic levels are available.Since the substance is susceptible to abiotic hydrolysis (DT50: 1.24 d (pH7) and 2.98 h (pH8) (HYDROWIN v2.00)) it is likely that the possible effects of the parent substance as well as the hydrolysis products were assessed in the available studies. Further analytical investigations in the available ecotoxicological studies resulted in DT50 values of 4 h in standard algae medium (OECD 201; Vryenhoef, 2013) and 11 h in standard daphnia medium (OECD 202; Vryenhoef, 2012).
In the available studies aquatic algae turned out to be the most sensitive species (EC50 (72 h): 38 mg/L). No short-term toxicity to aquatic invertebrates was observed resulting in an EC50 (48 h) > 100 mg/L (nominal). The short-term toxicity study to fish (OECD 203) is still on-going. The dossier will be updated as soon as possible and the Chemical Safety Assessment according to Annex I of Regulation (EC) No 1907/2006 will be re-evaluated based on the outcome of this new study.
The environmental exposure assessment for ethylene diformate according to Annex XI, Section 3 indicates no risk for the aquatic compartment (all RCR < 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information). Thus, long-term testing with aquatic invertebrates and fish is not deemed necessary.
Ethylene diformate is readily biodegradable. Moreover, the test substance caused no inhibition of biodegradation and was not toxic to the inoculum in a toxicity control included in a standard biodegradation study according to OECD 301B (NOEC ≥ 28.4 mg/L). Therefore, inhibition of the subsequent degradation process in sewage treatment plants is not expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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