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EC number: 210-157-9 | CAS number: 608-27-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No reliability is given as this is an applicant's summary entry for a variety of studies.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- A comparative study of the toxicity of 1,1,2-trichloroethane, Dieldrin, Pentachlorophenol and 3,4-dichloroaniline for marine and fresh water organisms
- Author:
- Adema DMM, Vink GJ
- Year:
- 1 981
- Bibliographic source:
- Chemosphere Vol. 10, No. 6, 533-554
- Reference Type:
- other: secondary source
- Title:
- 3,4-dichloroaniline (3,4-DCA)
- Author:
- EU-Risk Assessment Report
- Year:
- 2 006
- Bibliographic source:
- EUR 22235 EN; ISSN 1018-5593
- Reference Type:
- other: Expert Statement
- Title:
- 2,3-dichloroaniline (CAS 608-27-5) Read-across justification
- Year:
- 2 022
Materials and methods
- Principles of method if other than guideline:
- TNO (1980): Degradability, Ecotoxicity and Bioaccumulation; The determination of the possible effects of chemicals and wastes on the aquatic environment. Government Publishing Office, The Hague, The Netherlands.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,3-dichloroaniline
- EC Number:
- 210-157-9
- EC Name:
- 2,3-dichloroaniline
- Cas Number:
- 608-27-5
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 2,3-dichloroaniline
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Sampling method: concentration of the test compound was measured by chemical analysis during the test and was at least 70% of the nominal value
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Age at study initiation: life stage: larvae
- Length at study initiation: 1 mm
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- pH:
- the pH was measured during the test and was always about 8
- Dissolved oxygen:
- the oxygen concentration was measured during the test and was never less than 70% of the saturation value
- Nominal and measured concentrations:
- measured concentration was at least 70% of the nominal value
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.16 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.23 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Any other information on results incl. tables
Read across (3,4-dichloroaniline): LC50 (Daphnia, 48-h): 0.23 mg/L (Adema. and Vink, 1981; cited in EU RAR, 2006)
Applicant's summary and conclusion
- Conclusions:
- The most critical valid short-term LC50 (48h) is 0.23 mg/L on Daphnia magna (Adema. and Vink, 1981) which was experimentally determined.
- Executive summary:
In this read-across approach data on 3,4-dichloroaniline (CAS 95-76-1, source substance) is used to fill data gaps for 2,3-dichloroaniline (CAS 608-27-5, target substance). According to the “Read-Across Assessment Framework” (RAAF) (ECHA 2017) the analogue approach is followed. Data on 3,4-dichloroaniline (CAS 95-76-1) is used to fill data gaps for 2,3-dichloroaniline (CAS 608-27-5). The target substance is a basically an isomer of the source substance. The physical and chemical properties of the source and the target substance are in the same range. Both, the source and the target substance have a log Pow value of less than 3, which implies a low potential to bioaccumulation. Thus, the source and the target substance may be excreted quickly and are not expected to bioaccumulate in the food chain. However, 3,4-dichloroaniline has shown significant ecotoxicity based on tests done on fish, daphnids and algae. Hence, based on the structural similarity, the similar physico-chemical properties, and the fact that the structural difference in the source substance indicates a slightly higher toxicity when compared to the target substance, the target substance as such does not need to be tested in aqueous system. It is sufficient for hazard assessment to use the data gained with 3,4-dichloroaniline. This can be regarded as worst-case for the target substance. For more details please see attached read-across statement.
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