Registration Dossier

Administrative data

Description of key information

Oral (Rat, equivalent to OECD TG 423): LD50 > 2000 mg/kg
[Schering AG, Report -draft-, 1994-09-23]
Dermal (Rat, GLP, equivalent to OECD TG 402): LD50 > 2000 mg/kg
[Schering AG, Report -draft-, 1994-10-19]

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
2 000 mg/kg bw

Additional information

The single oral administration of the test substance (ZK 10882) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs were observed and there were no macroscopic pathological signs.

The acute oral toxicity of 6 -Chlor-Chlormethyldien in rats is therefore above 2000 mg/kg body weight.

The single dermal administration of the test substance (ZK 10882) to male and female rats at the limit dose of 2000 mg/kg was tolerated without any mortality. No compound-related findings were observed with regard to local and clinical observation, determination of body weight and necropsy examination.

The acute dermal toxicity of 6 -Chlor-Chlormethyldien in rats is therefore above 2000 mg/kg body weight.

No local intolerance reactions at the application sites were observed.

Justification for classification or non-classification

Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.