Registration Dossier
Registration Dossier
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EC number: 206-055-9 | CAS number: 298-06-6
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to aquatic invertebrates
"EP-1, potassium salt" was tested for the acute toxic effects on the crustacean Acartia tonsa in accordance with the DS/EN ISO 14669 guideline of 1999. The test was carried out in 50 mL test beakers with 25 mL of test solution in each beaker. The number of dead animals was counted after 24 and 48 hours; total exposure time was 48 hours.
A stock solution of EP-1 potassium salt was prepared by dissolving 400 mg of the test substance in 200 mL seawater, thereby generating a concentration of 2000 mg/L of EP-1 potassium salt. From this, the follwing test concentrations were generated (dilution in seawater): 100, 200, 500, 1000 and 2000 mg/L. Seawater without test substance served as negative control. As reference substance, 3,5 -DCP was used, to test the sensitivity of the test organism.
Chemical analysis revealed that the actual concentration in the stock solution was 1960 mg/L which is equivalent to the nominal concentration. The toxicity of the reference substance was within the expected range.
The results of the study expressed in nominal concentrations can be summarized as follows:
LC10 = 529 mg/L after 48 hours of exposure,
LC50 = 1271 mg/L, after 48 hours of exposure,
LC90 > 2000 mg/L, after 48 hours of exposure.
Short-term toxicity to algae
The test substance EP-1 potassium salt was tested for inhibitory effects on the growth of the marine microalgae Skeletonema costatum according to OECD guideline 201 and ISO 10253.
The test was carried out in 250 mL flasks with approximately 70 mL of test solution per flask. The growth of the algae was measured as fluorescence every 24 hours during the test. The total exposure time was 72 hours.
Chemical analysis revealed that the actual concentration of the stock solution was 1850 mg/L, which is close to the nominal concentration of 1880 mg/L.
The results of the study expressed in nominal concentrations can be summarized as follows:
The NOEC and LOEC for the growth rate were 1000 mg/L and 1800 mg/L, respectively and the EC10 and EC50 values for the growth rate were 1026 mg/L and >1800 mg/L, respectively.
The overall evidence indicates that EP-1, potassium salt, does not need to be classified and labelled with respect to aquatic toxicity.
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