Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-490-4 | CAS number: 349-76-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Oct to 05 Nov 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal Register 40 CFR Part 796.1840
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 622.8 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 8.1 g/L
- Incubation duration:
- 3 d
- Temp.:
- 25 °C
- pH:
- 7.78
- Remarks on result:
- other: centrifugation: 30000 G
- Water solubility:
- 631.7 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 7.91 g/L
- Incubation duration:
- 2 d
- Temp.:
- 25 °C
- pH:
- 7.76
- Remarks on result:
- other: centrifugation: 30000 G
- Water solubility:
- 620.8 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 7.92 g/L
- Incubation duration:
- 1 d
- Temp.:
- 25 °C
- pH:
- 7.73
- Remarks on result:
- other: centrifugation: 30000 G
- Water solubility:
- 608.4 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 7.98 g/L
- Incubation duration:
- 3 d
- Temp.:
- 25 °C
- pH:
- 7.83
- Remarks on result:
- other: centrifugation: 50000 G
- Water solubility:
- 599.6 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 8.11 g/L
- Incubation duration:
- 2 d
- Temp.:
- 25 °C
- pH:
- 7.74
- Remarks on result:
- other: centrifugation: 50000 G
- Water solubility:
- 615.2 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 8.02 g/L
- Incubation duration:
- 1
- Temp.:
- 25 °C
- pH:
- 7.67
- Remarks on result:
- other: centrifugation: 50000 G
- Details on results:
- The average of the water solubility was determined as 620 mg/L at 25 °C.
- Conclusions:
- The test item has a water solubility of 620 mg/L at 25 °C, pH ca. 7.7
- Executive summary:
A study was conducted to assess the water solublility of the test substance in accordance to OECD guideline number 105, the EC method A.6 and the US Federal Register 40 CFR Part 796.1840 using the "flask method".
On each of the first three days of the main experiment two test dispersions, each containing about thirteen times tbe amount of test substance necessary for saturation, were prepared in stainless steel centrifuge tubes and equilibrated by continuous shaking at 30.0 °C (± 0.1 °C) in a thermostatically controlled water bath. On the fourth day the temperature of the water bath was reduced to 25.0 °C (± 0.1 °C), at which temperature the six test dispersions were then shaken for a further 24 hours. The centrifuge tubes were tbeit centrifuged for 40 minutes at 30000 G or 50000 G in a thermostated centrifuge (25 °C). Subsequently, an aliquot from each clear, saturated solution was removed and analysed by high petfonnancc liquid chromatography (HPLC).
The water solubility of the test substance was determined as 620 mg/L at 25 °C, pH ca. 7.7.
Reference
Description of key information
A study was conducted to assess the water solublility of the test substance in accordance to OECD guideline number 105, the EC method A.6 and the US Federal Register 40 CFR Part 796.1840 using the "flask method".
On each of the first three days of the main experiment two test dispersions, each containing about thirteen times tbe amount of test substance necessary for saturation, were prepared in stainless steel centrifuge tubes and equilibrated by continuous shaking at 30.0 °C (± 0.1 °C) in a thermostatically controlled water bath. On the fourth day the temperature of the water bath was reduced to 25.0 °C (± 0.1 °C), at which temperature the six test dispersions were then shaken for a further 24 hours. The centrifuge tubes were tbeit centrifuged for 40 minutes at 30000 G or 50000 G in a thermostated centrifuge (25 °C). Subsequently, an aliquot from each clear, saturated solution was removed and analysed by high petfonnancc liquid chromatography (HPLC).
The water solubility of the test substance was determined as 620 mg/L at 25 °C, pH ca. 7.7.
Key value for chemical safety assessment
- Water solubility:
- 620 mg/L
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
