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Diss Factsheets
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EC number: 213-983-8 | CAS number: 1070-89-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information from published industry source (USEPA), limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Two Sprague-Dawley rats per sex per dose group were exposed by inhalation to the test substance for 4 hours. After an observation period of 14 days, animals were necropsied.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,1,3,3,3-hexamethyldisilazane
- EC Number:
- 213-668-5
- EC Name:
- 1,1,1,3,3,3-hexamethyldisilazane
- Cas Number:
- 999-97-3
- Molecular formula:
- C6H19NSi2
- IUPAC Name:
- 1,1,1-trimethyl-N-(trimethylsilyl)silanamine
- Details on test material:
- - Name of test material (as cited in study report): Hexamethyldisilazane
- Molecular formula (if other than submission substance): C6H19NSi2
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 250 g
- Housing: individually, stock cages
- Diet: ad libitum, standard laboratory rat diet from Wayne Lab Blox, Allied Mills, Chicago, Illinois
- Water: ad libitum
- Acclimation period: 5 days
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass inhalation chamber
- Exposure chamber volume: 5.5 liter
- System of generating vapour: vapours were produced by bubbling dried metered arid thorugh the undiluted test material. Additional dried metered air was mixed with the vapour stream to achieve the desired concentration levels.
POSITIVE CONTROL
- No. of animals: 4 groups of 2 animals per sex per dose
- Positive control compound: 10% ammonium hydroxide solution
- Concentrations: 8.5, 18.9, 33, 72.5 mg/L air - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Remarks on duration:
- Except 60.5 and 94.3 mg/L dose group, which were exposed 110 and 70 min., resp.
- Concentrations:
- 5.6, 19, 30.4, 60.5, 94.3 mg/L air
- No. of animals per sex per dose:
- 2
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- The mortality data were analyzed statistically, employing the technique of Litchfield and Wilcoson (J.T. Litchfield, Jr. and F. Wilcoxon, "A Simplified Method of Evaluating Dose-Effect Experiments." J. Pharm. & Exp. Ther., Vol 96, No. 2, pp. 99-113, 1949.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 10.3 mg/L air
- Based on:
- test mat.
- 95% CL:
- 6.4 - 16.5
- Exp. duration:
- 4 h
- Mortality:
- - No mortality observed in animals exposed to 5.6 mg/L
- All animals exposed to 19, 30.4, 60.5, 94.3 mg/L died, within 70 minutes to 48 hours after exposure - Clinical signs:
- other: - Hypoactivity, hyperpnoea and ataxia were observed in animals exposed to 30.4, 60.5 or 94.3 mg/L, after 4 to 14 minutes of exposure. Sedation was noted at the 10 to 21 minute point. Sedation and hyperpnoea persisted until death. - Hypoactivity was observ
- Gross pathology:
- - Necroscopy revealed mild lung haemorrhage in animals exposed to 19, 30.4, 60.5 or 94.3 mg/L hexamethyldisilazane.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
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