Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 309-849-4 | CAS number: 101316-44-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study meets generally accepted scientific principles as a modification of a standard Draize test procedure, selection of test concentrations based on preliminary irritation tests both for intradermal injection and topical application, suffcient description of test protocol; minor restrictions: only qualitative test result presented in a table, no data on sensitisation scores for the test group or individual test animals; limited number of 10 test animals, no replicate study; study acceptable as supporting information
Data source
Reference
- Reference Type:
- publication
- Title:
- The sensitization potential of some perfume ingredients tested using a modified Draize procedure
- Author:
- Sharp DW
- Year:
- 1 978
- Bibliographic source:
- Toxicology 9: 261-271
Materials and methods
- Principles of method if other than guideline:
- Draize test with modified protocol for induction
- GLP compliance:
- no
- Type of study:
- Draize test
Test material
- Reference substance name:
- Acetophenone
- EC Number:
- 202-708-7
- EC Name:
- Acetophenone
- Cas Number:
- 98-86-2
- Molecular formula:
- C8H8O
- IUPAC Name:
- 1-phenylethanone
- Details on test material:
- Purity: commercial batch
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: inbred from own colony
- Weight at study initiation: 350 g
- Housing: in pairs
- Diet: ad libitum
- Water: ad libitum
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- no data
- Concentration / amount:
- Intradermal injection challenge concentration (ICC): 0.25 %
Topical application challenge concentration (ACC): 20 %
Challengeopen allclose all
- Route:
- intradermal and epicutaneous
- Vehicle:
- no data
- Concentration / amount:
- Intradermal injection challenge concentration (ICC): 0.25 %
Topical application challenge concentration (ACC): 20 %
- No. of animals per dose:
- 10
- Details on study design:
- - Induction treatment:
0.1 ml aliquots of the test substance at 2.5 times the injection challenge concentration were administered on one occasion as 4 intradermal injections at 4 sites which overlie the 2 auxiliary and 2 inguinal lymph nodes. Induction time was 14 days.
- Challenge treatment:
Intradermal injection in one flank and topical application on the other flank by spreading 0.1 ml of the test substance onto the shaved flank in a small circular area which was not covered.
- Scoring of reactions:
24 hrs later
Apparent sensitization reactions were confirmed 7 days later by a second challenge.
In the absence of sensitisation reactions at first challenge, the induction and challenge procedures were repeated, but htis time a confirmatory challenge with controls was included.
- Controls:
At each challenge 4 previously untreated animals of the same sex and similar weight to the test animals were treated intradermally and topically on opposite flanks with 0.1 ml aliquots of test substance at the ICC and ACC, respectively.
- Scoring:
Injection reaction: total score based on size, erythema and oedema.
Positive reaction: total score of individual reaction significantly greater than the total average score for control reactions.
Application reaction: 0 to +++ scale
Positive reaction: (a) scoring >= + and (b) no erythema reactions in controls - Positive control substance(s):
- yes
- Remarks:
- other test substances that yielded positive test results
Results and discussion
Any other information on results incl. tables
Negative (no details of test results reported).
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Acetophenone was assessed as non-sensitiser in a modified Draize test with Hartley guinea pigs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.