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EC number: 257-027-8 | CAS number: 51167-18-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study is a screening test but followed international guidance requirements with acceptable restrictions. As this study is more recent and more details about the experimental conditions were available compared to the study performed in 1998, the study performed in 2006 was considered as the more reliable and relevant and considered as the Key study.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
- Principles of method if other than guideline:
- Another screening study on the test material was available showing a LD 50 of approximately 25 mg/kg bw (study considered as a supporting study in the present dossier). The study in 2006 was performed in order to refine the result obtained previously. 3 different single oral doses were administered by gavage to 3 different female rat groups.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide
- EC Number:
- 257-027-8
- EC Name:
- 2'-[2,4-dichloro-5-(1-methylethoxy)phenyl]-2,2-dimethylpropionohydrazide
- Cas Number:
- 51167-18-1
- Molecular formula:
- C14H20Cl2N2O2
- IUPAC Name:
- N'-(2,4-dichloro-5-isopropoxyphenyl)-2,2-dimethylpropanehydrazide
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): HTMA
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Fasting period before study: overnight
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous methylcellulose
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 mL/kg bw - Doses:
- 50; 100 and 200 mg/kg bw
- No. of animals per sex per dose:
- 3 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 8 days
- Frequency of observations and weighing: daily observations, weighing on study 1 and at termination
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 Finney calculation
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 114.17 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 200 and 100 mg/kg bw, 2/3 animals were sacrificed moribund on the study day 3. At 50 m/Kg bw, no death occurred.
- Clinical signs:
- other: At 100 and 200 mg/kg bw, before death animals were prostated and had a reduced motor activity. At 50 mg/kg bw, no clinical signs were recorded.
- Gross pathology:
- no data
- Other findings:
- no other findings
Any other information on results incl. tables
no other information.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, 2'-(2,4-Dichloro-5-(1-methylethoxy)phenyl)-2,2-dimethylpropionohydrazide is toxic to the female rat after a single oral dose administration. As the LD50 is 114.17 mg/kg bw, 2'-(2,4-Dichloro-5-(1-methylethoxy)phenyl)-2,2-dimethylpropionohydrazide is classified as Acute tox 3 (H301) according to the Regulation (EC) 1272/2008 (CLP) and as toxic if swallowed (T, R25) according to the Directive 67/548/EEC.
- Executive summary:
In an acute oral toxicity screening study, performed similarly to the OECD guideline No. 401, three groups of female rats (3 animals/dose) were given a single oral dose of undiluted 2'-(2,4-Dichloro-5-(1-methylethoxy)phenyl)-2,2-dimethylpropionohydrazide (named as HTMA in the study report) by gavage at the doses of 200; 100 and 50 mg/kg bw. Clinical signs, mortality and body weight gain were checked for a period of up to 8 days. No necropsy was performed.
Oral LD50rat (female) = 114.17 mg/kg bw
At 200 and 100 mg/kg bw, 2/3 animals were sacrificed moribund on the study day 3. At 50 m/Kg bw, no death occurred. At 100 and 200 mg/kg bw, before death animals were prostated and had a reduced motor activity. At 50 mg/kg bw, no clinical signs were recorded. All animals had a body weight gain between 14 and 19%.
Under the test conditions, 2'-(2,4-Dichloro-5-(1-methylethoxy)phenyl)-2,2-dimethylpropionohydrazide is toxic to the female rat after a single oral dose administration. As the LD50 is 114.17 mg/kg bw, 2'-(2,4-Dichloro-5-(1-methylethoxy)phenyl)-2,2-dimethylpropionohydrazide is classified as Acute tox 3 (H301) according to the Regulation (EC) 1272/2008 (CLP) and as toxic if swallowed (T, R25) according to the Directive 67/548/EEC. This study is considered as acceptable and satisfies the requirement for acute oral toxicity endpoint.
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