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Diss Factsheets
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EC number: 209-132-5 | CAS number: 556-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles. Data gap : data on patients (occupational status, age, clinical history)
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic contact dermatitis from methylisothiocyanate in soil disinfectants.
- Author:
- Richter G.
- Year:
- 1 980
- Bibliographic source:
- Contact dermatitis, 6 : 183-186.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Patch test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl isothiocyanate
- EC Number:
- 209-132-5
- EC Name:
- Methyl isothiocyanate
- Cas Number:
- 556-61-6
- Molecular formula:
- C2H3NS
- IUPAC Name:
- isothiocyanatomethane
- Details on test material:
- Vapam or Nematin 10% in water.
Vapam contains 29.5% MITC and Nematin contains 32.7% MITC.
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- Nine patients exposed to vapam or Nematin, with occupational dermatitis.
- Clinical history:
- no data
- Controls:
- no
- Route of administration:
- dermal
- Details on study design:
- Patch test to Vapam in a nonirritant concentration of 0.05 % in water was tested.
Results and discussion
- Results of examinations:
- Though all persons had contact with the soil disinfectants for a few days only; and one woman only a few hours, eight of the nine patients showed ++ or +++ positive patch test reaction to Vapam, and these results could be elicited again 1 year later.
Applicant's summary and conclusion
- Conclusions:
- The author concluded that MITC must be a very strong contact sensitizer.
- Executive summary:
The author recounted a number of dermatitis patients that showed positive patch test reaction to Vapam (metam sodium), concluding that the initial effector must have been MITC. One patient, exposed to dazomet throught rubber boots, developed burns and a bullous eruption agin one year later A further complication, "hypersensitivity-hepatitis of nonspecific type" was disgnosed after liver biopsy. While conditioning exposure to oral contraceptives was implicated in this response, Richter concluded that MITC absorption through the skin was also involved. Indeed, "such side effects must be considered if large areas of skin have been affected".
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