Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well-documented, guideline-conform study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1989

Report date:

1989

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

EC Number:

230-625-6

EC Name:

Tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

Cas Number:

7226-23-5

Molecular formula:

C6H12N2O

IUPAC Name:

tetrahydro-1,3-dimethyl-1H-pyrimidin-2-one

Test material form:

other: liquid

Details on test material:

Name of the test substance used in the study report: N,N'-Dimethylpropylenharnstoff

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

Five animals per cage were housed in stainless steel wire mesh cages. The animals were held in fully air-conditioned rooms with a central air conditioning in a range of 20 - 24°C and a relative humidity between 30 - 70%. The day/night rhythm was 12 h light and 12 h dark. The rats were identified using cage cards. A standardized rat feed diet and tap water were available ad libitum. The animals were given no feed about 16 h before administration; water was available ad libitum.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

681, 1470, 2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

Duration of observation period following administration: 14 days
Recording of signs and symptoms were done several times on the day of administration (at least once each working day). A check for moribund and dead rats were made twice each working day and once on public holidays.
Withdrawal of food about 15 hours before sacrifice with CO2; necropsy with gross-pathological examination. Necropsy was done of all a nimals that die as early as possible.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 770 mg/kg bw

Based on:

test mat.

Mortality:

Male animals: 681 and 1470 mg/kg: no mortalities after 14 days. 2000 mg/kg: 4/5 after 14 days.
Female animals: 681 mg/kg: no moralities after 14 days. 1470 mg/kg: 1/5 after 14 days. 2000 mg/kg: 4/5 after 14 days.

Clinical signs:

other: Dyspnea, apathy, staggering, twitching, piloerrection, cyanosis (males only), impaired general state (females only) poor general state.

Gross pathology:

Animals that died: general congestion; lungs: intensified hyperemia in few animals.
Sacrificed animals: nothing abnormal detected.

Applicant's summary and conclusion

Interpretation of results:

moderately toxic

Remarks:

Migrated information