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EC number: 242-217-5 | CAS number: 18328-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1986 to January 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data presented as a summary report to TSCA under the Section 8 (e) Compliance Audit Programme for Reportable Adverse Effects. A full study report is not available for evaluation of the overall study reliability but the data summary presented to TSCA are adequate to determine the acute endpoint.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Three group oral toxicity study similar to the OECD 401 test guidelines.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-ethyl methyl allylamine
- IUPAC Name:
- N-ethyl methyl allylamine
- Reference substance name:
- N-ethylmethacrylamine
- EC Number:
- 242-217-5
- EC Name:
- N-ethylmethacrylamine
- Cas Number:
- 18328-90-0
- Molecular formula:
- C6H13N
- IUPAC Name:
- N-ethyl-2-methylprop-2-en-1-amine
- Test material form:
- other: clear yellowish liquid
- Details on test material:
- - Name of test material (as cited in study report): C-1033 (N ethyl methyl allylamine)
- Physical state: clear yellowish liquid
- Analytical purity: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Storage condition of test material: 60-85°F (circa 16-30°C)
- Other: Specific Gravity stated as 0.78 g/mL
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No information
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No information
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: animals received on 16 or 23 September or 9 December 1986 and dosed on 9 or 16 October or 31 December respectively
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Room monitored over temperature range of circa 16-30°C
- Humidity (%): No information
- Air changes (per hr): No information
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: 9 October 1986 To: 7 January 1987
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
MAXIMUM DOSE VOLUME APPLIED:6.4 mL C-1033 was administered undiluted as 0.06 ; 0.64 and 6.4 ml to achieve dose levels of 50, 500 or 5000 mg/kg assuming a Specific Gravity value of 0.78 g/ml
DOSAGE PREPARATION (if unusual): not applicable- Doses:
- 50, 500 and 5000 mg/kg
- No. of animals per sex per dose:
- six
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, record of mortalities - Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 50 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 3 of 6 rats dosed at 50 mg/kg bw died and all of the rats dosed at 500 or 5000 mg/kg bw died
- Mortality:
- 3 of 6 rats died at 50 mg/kg bw
6 of 6 rats died at 500 mg/kg bw
6 of 6 rats died at 5000 mg/kg bw - Clinical signs:
- other: At 5000 mg/kg bw: No signs noted At 500 mg/kg bw: The following signs were observed but no details of time of onset, duration, incidence within group or severity are indicated - Fine tremors, red nasal discharge, dyspnoea, abdominal griping, hypoactivity
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
No further information
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was determined to be 50 mg/kg bw.
- Executive summary:
In an acute oral toxicity study, three groups of six rats were dosed with undiluted C-1033 (N-ethylmethylallylamine), by oral gavage, at dose levels of 50, 500 or 5000 mg/kg bw. Three of six rats dosed at 50 mg/kg bw died and ante-mortem clinical signs included red nasal and oral discharges, oral discharge, hypopnoea, dyspnoea, unthrifty hair coat, abdominal griping, partially closed eyes, hypoactivity, decreased or no food consumption. All of the rats dosed at 500 or 5000 mg/kg died and while no clinical signs were noted in the high dose group, a similar clinical profile was observed in the 50 and 500 mg/kg groups. The LD50 was therefore determined to be 50 mg/kg bw.
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