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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Endpoint summary

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Administrative data

Description of key information

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Qualifier:
according to guideline
Guideline:
OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
Deviations:
no
GLP compliance:
yes
Test system:
artificial membrane barrier model
Source species:
human
Cell type:
non-transformed keratinocytes
Cell source:
other: not specified
Source strain:
not specified
Vehicle:
unchanged (no vehicle)
Control samples:
yes, concurrent negative control
yes, concurrent positive control
Amount/concentration applied:
as poder
Duration of treatment / exposure:
3min, 60 min
Duration of post-treatment incubation (if applicable):
3min, 60 min
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
3 min
Value:
41
Vehicle controls validity:
not specified
Negative controls validity:
valid
Remarks:
100
Positive controls validity:
valid
Remarks:
16.3
Irritation / corrosion parameter:
% tissue viability
Run / experiment:
60 min
Value:
0
Vehicle controls validity:
not specified
Negative controls validity:
valid
Remarks:
100
Positive controls validity:
valid
Remarks:
4.8
Interpretation of results:
Category 1C (corrosive) based on GHS criteria
Conclusions:
The outcome of the study predicted, that the test substance is corrosive to skin
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)
Reason / purpose for cross-reference:
reference to other study
Interpretation of results:
Category II
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
stimulationtin monoxide is completely insoluble , inorganic substance, no bioavailability, so only mechanical stimulation or injuries feasible
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of skin irritation / corrosion endpoint:
Data from OECD 412 study show no adverse effect

Justification for selection of eye irritation endpoint:
mechanical irritation of cornea by stubstance

Effects on eye irritation: irritating

Justification for classification or non-classification