Registration Dossier
Registration Dossier
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EC number: 292-474-2 | CAS number: 90622-71-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-10-29 to 1996-11-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study OECD 405, OECD 1981; updated guideline, adopted 1987-02-24. Deviation: The purity of the test substance is not mentioned
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Perfluoralkyljodid 612
- IUPAC Name:
- Perfluoralkyljodid 612
- Details on test material:
- - Molecular formula (if other than submission substance): C2F5(C2F4)nJ; (n= 2-5)
- Molecular weight (if other than submission substance): 530g/mol
- Physical state: violet fluid
- Analytical purity: n/a
- Impurities (identity and concentrations): n/a
- Composition of test material, percentage of components: n/a
- Lot/batch No.: P.96029
- Expiration date of the lot/batch: 1998-07-16
- Storage condition of test material: darkness at room temperature in a fume cupboard
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24h after application eyes were rinsed with isotonic saline at approx. 37°C
- Observation period (in vivo):
- 1, 24, 48 and 72 hours after application of the test substance.
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks:
- #1, #2, #3
- Time point:
- other: 24h, 48h and 72h after application of test substance
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: none
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the test results the test substance is not irritating to the eye
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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