Registration Dossier
Registration Dossier
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EC number: 233-897-4 | CAS number: 10420-33-4
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity, OECD401, EU B.1: LD50 >2000 mg/kg body weight
Acute toxicity via inhalation: Waiver, see also below.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In an acute oral toxicity study with rats the LD50 was greater than 2000 mg per kg body weight.
Acute toxicity, inhalation:
Using the correct melting point of 31.1 °C, the vapour pressure of DMAS has been estimated to be 19.6 Pa. This is equivalent with an exposure level of 193 ppm (1490 mg/m3). A rat inhales during an hour 40 litres of air per kg bodyweight or 160 litres (=0.16 m3) during 4 hours. So during 4 hours a rat inhales 0.16*1490 = 238 mg/kg bw. This means that at saturated vapour pressure there is no risk of acute inhalation toxicity by inhalation of saturated DMAS vapour for 4 hours. Under normal operations in a production plant only one tenth of the vapour pressure may occur during short term operations (15 to 30 minutes), which means that the risk of inhalation toxicity is practically non existing in case of handling DMAS at ambient temperature.
Justification for classification or non-classification
According to the results of an acute oral toxicity study and the conclusions drawn for exposure via inhalation no classification is derived for the test item.
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