Sulfuric acid, mono-C8-10-alkyl esters, sodium salts

Short-term toxicity to fish

Description of key information

48hr LC50 (Cyprinus carpio pre-larvae, mortality) = 13 mg/L (nominal concentration, Japanese Industrial Standard JIS K0102)

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

13 mg/L

Additional information

Since no studies investigating the short-term fish toxicity of C8-10AS Na (CAS 85338-42-7) are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to other structurally related category members was conducted. Read-across data from the pure homologues C8AS Na (CAS 142-31-4) and C10AS Na (CAS 142-87-0) were used.

Three reliable short-term studies with fish are available for C10AS Na (CAS 142-87-0). In the key, non-GLP study performed according to Japanese Industrial Standard JIS K0102, 1-week old carp pre-larvae (Cyprinus carpio) were exposed to C10AS Na for 48 hours under static conditions (Kikuchi et al. 1976a). Based on pre-larvae mortality, the LC50 value was 13 mg/L (nominal concentrations in agreement with the measured ones). Since this value was the most critical, it is treated as the reliable and conservative short-term LC50 value for fish. The same authors provide supporting information on Carp egg hatching rate influenced by C10AS Na (Kikuchi 1976b). Fish eggs were exposed for 96 hours to the test concentrations up to 100 mg/L (nominal concentrations in agreement with the measured ones). The study followed Japanese Industrial Standard JIS K0102. Inhibition of hatching rate could not be calculated because hatching rate was higher at 70 mg/L (ca. 40%) than at 50 mg/L (ca. 12%). No hatching at 100 mg/L was observed. Hatching rate in control group was 87.3%. The last non-GLP supporting study with C10AS Na (CAS 142-87-0) was performed according to ISO 7346-1 guidance (Richterich 2001). Mortality of zebrafish (Danio rerio) was determined after 24, 48, 72 and 96 hours of exposure to five test concentrations up to 1000 mg/L of product containing 30% of active ingredient and 70% water (nominal concentrations). Analytical monitoring was not performed. The results showed that the 96-hour LC50 value was 177 mg a.i./L (nominal concentration).

Moreover, two short-term fish tests are available for C8AS Na (CAS 142-31-4). The first, GLP study was performed according to OECD 203 guideline (Neven 1993). Zebrafish (Danio rerio) were exposed for 96 hours to five test concentrations up to 100 mg/L (nominal concentrations in agreement with the measured ones). Since no toxic effects were observed up to the highest test concentration, the 96-hour LC50 value was determined above 100 mg/L (nominal concentration). The supporting non-GLP test was performed test according to DIN 38412 - L15 guideline (Richterich 2001). Golden orfes (Leuciscus idus) were exposed for 48 hours to five concentrations up to 1000 mg/L of 40% pure test substance, which was equal to 400 mg/L of active ingredient (nominal concentrations, analytical measurements are not available). The 48-hour LC50 value was determined as 172 mg/L (nominal concentration).

Due to structural and property similarities with the tested category members, the above results apply also to C8-10AS Na (CAS 85338-42-7). The 48-hour LC50 value of 13 mg/L is the most critical short-term value for fish.