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EC number: 700-740-0 | CAS number: 1103234-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov-Dec 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study conducted under GLP conditions and in acc. with OECD guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 302 C (Inherent Biodegradability: Modified MITI Test (II))
- Principles of method if other than guideline:
- This·study differed in three points from the test protocol described in the OECD test
guideline 302 C:
• In the OECD 302 C guideline a toxicity control is not included
• The sludge was only from one site, not from ten different sites
• A slightly different test medium was used, since a 1.5 times higher
concentration of Na2HP04 was added. As this is the concentration of Na2HP04 added in
the medium of the OECD 301 tests, negative effects on the sludge can be excluded. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid
- EC Number:
- 700-740-0
- Cas Number:
- 1103234-56-5
- Molecular formula:
- C10H11F2NO4S
- IUPAC Name:
- 2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid
- Details on test material:
- -Substance type: organic
-Physical state: solid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- Inoculum: Not adapted activated sludge from the aeration tank of the ARA Werdholzli (CH-8048 Zurich), a
municipal biological waste water treatment plant.
1 00 mg/1 dry matter in the final mixture. - Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- 30 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- The activated sludge was used after sampling from the treatment plant without
adaptation. However, the sludge was pre-conditioned for 1 day (aerated but not fed)
to reduce the amount of 0 2 consumed by the blank controls.
Prior to the test the sludge was washed twice with tap water. The test material was
directly added to the test solutions to give a final test concentration of about 30 mg/1.
The reference compound sodium benzoate was applied at a concentration of about
100 mg/1. In the toxicity control about 30 mg/1 test material and about 30 mg/1
reference material were applied simultaneously.
The test vessels were stirred by an inductive stirring system for a maximum test
period of 28 days. During the test the 0 2 uptake is continuously measured with a
manometric BOO measuring device. The pH-value was checked at the beginning
and at the end of the test and was adjusted to pH 7.2 (± 0.2) with NaOH or H2S04 at
the beginning of the test, respectively.
The biodegradation of the test material was followed by daily measurements.
Additionally, ultimate biodegradation was determined based on the theoretical
carbon content and the analyses of dissolved organic carbon (DOC) concentrations
at the end of the test.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- mg/l
- Value:
- 0
- Sampling time:
- 0 d
- Remarks on result:
- other: mean of 3 test units
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- mg/l
- Value:
- 3.3
- Sampling time:
- 7 d
- Remarks on result:
- other: mean of 3 test units
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- mg/l
- Value:
- 6.7
- Sampling time:
- 14 d
- Remarks on result:
- other: mean of 3 test units
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- mg/l
- Value:
- 1.7
- Sampling time:
- 28 d
- Remarks on result:
- other: mean of 3 test units
BOD5 / COD results
- Results with reference substance:
- 79% biodegadability within 7 Days
86% biodegadability within 14 Days
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- Based on the data of the individual 02 determinations, no
biodegradability in the Modified MITI Test (11) of SAC-Sulfonamidsaure was observed during 28 days. - Executive summary:
The biodegradability of SAC-Sulfonamidsaure exposed to microorganisms derived from activated sludge of a municipal sewage treatment plant was investigated under aerobic static exposure conditions in the Modified MITI Test (11). No biodegradability of SAC-Sulfonamidsaure based on 02 consumption was observed during 28 days as compared to the theoretical oxygen demand (ThOD). At the applied initial test concentration of 30.0 mg/1 the test substance showed no significant toxic effect on the microbial population, since the biodegradation of the mixture (test substance + reference compound sodium benzoate) was within the expected theoretical value during the whole test period. The procedure control sodium benzoate reached 79 and 86% biodegradation after 7 and 14 days, thus confirming suitability of inoculum and test conditions. The calculated elimination based on DOC measurement reached 5% for SACSulfonamidsaure and 99% for sodium benzoate. The data show that SAC-Sulfonamidsaure will not be retained in sewage treatment plants. Based on these results SAC-Sulfonamidsaure cannot be termed as inherently biodegradable in the Modified MITI Test (11), since less than 20% degradation was attained after 28 days of incubation.
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