Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-074-4 | CAS number: 1490-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- The day before the experiment was started the rabbits were weighed and an area of 10 x 10 cm on the back was clipped as closely as possible with an electric clipper.
On the experimental day the rabbits were physically restrained on a test table, and the backs were treated on six different fields: Two anterior treatment sites, two centrally located test sites and two posterior treatment sites. To each of the fields about 0.5 ml of one of the test concentrations was applied and covered with gauze packs, 2.5 x 2.5 cm. The gauze packs were secured with a cross of 1 cm wide adhesive tape and fixed with Scanpor tape, 7.5 cm width, loosely wound round the trunk. Five test concentrations were used: 100%, 50%, 25%, 5%, or 1%.
After an exposure time of 4 hours the tape and packs were remoced and the reated skin was cleaned
with soap and lukewarm water. The skin reactions were read - GLP compliance:
- yes
Test material
- Reference substance name:
- DL-menthol
- EC Number:
- 216-074-4
- EC Name:
- DL-menthol
- Cas Number:
- 1490-04-6
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
- Details on test material:
- Test substance: menthol racemic
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other: diethylphthalate (DEP)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4.5, 24, 48, and 72 hours, 7, and 14 days
- Number of animals:
- 4 female rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: undiluted material
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hours
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- other: undiluted material
Any other information on results incl. tables
On day 7, all sites treated with a 100% concentartion wer covered with a massive layer of white-brown
seales on three test animals and the test site ofone test animal was covered with a thin
layer of white scales. Sites treated with a 50% concentration showed white scales on all rabbits. The test
sites, treated with a 25% concentration showed scattered white scales on one rabbit.
On day 14, the sites treated with a 100% concentration was still covered with white to white-brown
scales, but the underlying skin was intact. The sites treated with a 50% concentration showed scattered
seale formation on intact skin on 3 of the test animals.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information undiluted material
- Executive summary:
The day before the experiment was started the rabbits were weighed and an area of 10 x 10 cm on the back was clipped as closely as possible with an electric clipper.
On the experimental day the rabbits were physically restrained on a test table, and the backs were treated on six different fields: Two anterior treatment sites, two centrally located test sites and two posterior treatment sites. To each of the fields about 0.5 ml of one of the test concentrations was applied and covered with gauze packs, 2.5 x 2.5 cm. The gauze packs were secured with a cross of 1 cm wide adhesive tape and fixed with Scanpor tape, 7.5 cm width, loosely wound round the trunk. Five test concentrations were used: 100%, 50%, 25%, 5%, or 1%.
After an exposure time of 4 hours the tape and packs were remoced and the treated skin was cleaned with soap and lukewarm water. The skin reactions were read.
With the undiluted test substance menthol was irritating to the skin (erythema sore: 3 and and edema score: 3). The undiluted compounds were irritating to the skin. Dilution of the compounds led to a pronounced decrease in the irritating properties of the
compounds. No skin reaction at all were observed for D-menthol and menthol liquid at 5 % dilution and for L- and D/L-menthol at 1 % dilution.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.