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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficiently documented study report.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Unnamed
Year:
1977
Report date:
1977
Reference Type:
secondary source
Title:
Unnamed
Year:
2000

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No data available
GLP compliance:
no
Test type:
other: no data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl maleate
EC Number:
210-848-5
EC Name:
Dimethyl maleate
Cas Number:
624-48-6
Molecular formula:
C6H8O4
IUPAC Name:
dimethyl (Z)-but-2-enedioate

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
1 909 mg/kg bw
Based on:
test mat.
Remarks on result:
other: A density of 1.15 g/mL was used.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information
Conclusions:
The LD50,oral,rat is 1909 mg/kg bw.
Executive summary:

An acute oral toxicity study with rats was performed. The LD50oral,rat is 1909 mg/kg bw.